4-Amino-1-Boc-piperidine

Base Information

• Chemical Name: 4-Amino-1-Boc-piperidine
• CAS No.: 87120-72-7
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• Hs Code.: 29339900
• European Community (EC) Number: 617-965-4,691-998-2
• DSSTox Substance ID: DTXSID40361501
• Nikkaji Number: J887.265A
• Wikipedia: Boc-4-aminopiperidine
• Wikidata: Q72438326
• ChEMBL ID: CHEMBL3904068
• Mol file: 87120-72-7.mol

Synonyms:4-Amino-1-Boc-piperidine;87120-72-7;Tert-butyl 4-aminopiperidine-1-carboxylate;1-boc-4-aminopiperidine;n-boc-4-aminopiperidine;N-Boc-4-amino piperidine;4-amino-1-n-boc-piperidine;MFCD01076201;tert-Butyl 4-amino-1-piperidinecarboxylate;1-boc-4-amino piperidine;1-n-boc-4-aminopiperidine;4-amino-piperidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 4-AMINO-, 1,1-DIMETHYLETHYL ESTER;1-t-butoxycarbonyl-4-aminopiperidine;4-Aminopiperidine-1-carboxylic acid tert-butyl ester;1-butyloxycarbonyl-4-amino-piperidine;4-Amino-1-tert-butoxycarbonylpiperidine;4-Amino-1-tert-butoxycarbonyl-piperidine;tert-butyl4-aminopiperidine-1-carboxylate;N-Boc-4-amino-piperidine;1-tert-Butoxycarbonyl-4-amino-piperidine;1-Boc-4-piperidinamine;N-Boc-4-piperidineamine;n-boc-4-amino-piperidine;1-Boc-4-amino-piperidine;tert-butyl 4-aminopiperidinecarboxylate;4-amino Boc-piperidine;4-amino-Boc-piperidine;Boc-4-amino-piperidine;4-Amino-1-(tert-butoxycarbonyl)piperidine;4-amino-1-bocpiperidine;4-amino-N-Bocpiperidine;1-Boc 4-aminopiperidine;Boc-(4-amino)piperidine;4-amino-n-boc piperidine;4-amino-N-boc-piperadine;4amino-1-BOC-piperidine;4-amino-N-Boc-piperidine;4-amino-1-boc piperidine;SCHEMBL8018;4-amino-1-N-Bocpiperidine;4-amino-1N-Boc-piperidine;N-1-BOC-4-aminopiperidine;n-1-boc-4-amino piperidine;1-N-Boc 4-amino piperidine;1-N-Boc-4-amino piperidine;1-N-Boc-4-amino-piperidine;4-amino-1-N-Boc piperidine;CHEMBL3904068;DTXSID40361501;t-butoxycarbonyl-4-aminopiperidine;4-Amino-1-Boc-piperidine, 97%;1-t-butoxycarbonyl4-aminopiperidine;BCP22981;CS-B0234;t-butyl 4amino-piperidinecarboxylate;4-amino-1-t-butoxycarbonylpiperidine;STL112267;t-butyl 4-amino-piperidinecarboxylate;t-butyl-4-amino-piperidinecarboxylate;AKOS005254553;1H-Pyrazole-1-aceticacid, ethyl ester;4-amino-n-(t-butoxycarbonyl)piperidine;AC-1803;PB18530;PS-6274;1-tert-butoxycarbonyl-4-aminopiperidine;t-butyl 4-amino-1-piperidinecarboxylate;t-butyl 4-aminopiperidine-1-carboxylate;1-(tert-butoxycarbonyl)4-aminopiperidine;4Amino-1-(tert-butoxycarbonyl)piperidine;t-Butyl 4-aminopiperidin-1-ylcarboxylate;4-amino-1-tert-butyloxycarbonylpiperidine;BP-10062;SY002102;tert-buty 4-aminopiperidine-1-carboxylate;tert-butyl 4-aminopiperdine-1-carboxylate;tert-butyl 4-aminopiperidin-1-carboxylate;1-(tert-butoxycarbonyl)-4-aminopiperidine;4-amino-1-tert-butyloxycarbonyl-piperidine;N-(tert-butoxycarbonyl-4-piperidinyl)amine;tert-butyl-4-aminopiperidine-1-carboxylate;1-tertiary butoxycarbonyl-4-aminopiperidine;4-amino-1-(tert-butoxycarbonyl)-piperidine;4-amino-1-(tert-butyloxycarbonyl)piperidine;4-amino-1-tert.-butyloxycarbonyl-piperidine;tert-butyl 4-amino-1-piperidine carboxylate;tert-butyl 4-amino-1-piperidyl carboxylate;tert-butyl 4-amino-piperidine-1-carboxylate;AM20110250;BB 0296138;FT-0601515;EN300-39611;1-TERT-BUTOXYCARBONYL-4-AMINO-PIPERIDINE;1,1-dimethylethyl 4-amino-1-piperidinecarboxylate;1,1-dimethylethyl 4-aminopiperidine-1-carboxylate;4-amino-piperidine carboxylic acid tert-butylester;4-amino-piperidine-carboxylic acid tertbutyl ester;4-aminopiperidine-1-carboxylic acid t-butyl ester;racemic tert-butyl 4-aminopiperidine-1-carboxylate;4-amino-1-(1,1-dimethyl-ethoxycarbonyl)piperidine;4-amino-piperidine carboxylic acid tert-butyl ester;4-amino-piperidine-carboxylic acid tert butyl ester;4-amino-piperidine-carboxylic acid tert-butyl ester;W-203990;4-Amino-1-piperidinecarboxylic Acid tert-Butyl Ester;4-amino-piperidine 1-carboxylic acid tert-butyl ester;4-amino-piperidine-l-carboxylic acid tert-butyl ester;4-amino-piperidine -1-carboxylic acid tert-butyl ester;4-amino-piperidine-1-carboxylic acid, tert-butyl ester;F0001-0005;Z390160176;4-amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;70W

Chemical Property of 4-Amino-1-Boc-piperidine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00456mmHg at 25°C
• Melting Point: 50 °C
• Boiling Point: 277.3 °C at 760 mmHg
• PKA: 10.10±0.20(Predicted)
• Flash Point: 121.5 °C
• PSA: 55.56000
• Density: 1.041 g/cm³
• LogP: 1.98280
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 200.152477885
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

98% Min ^*data from raw suppliers

4-Amino-1-Boc-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38-20/21/22-20/21/2236/37/38
• Safety Statements: 26-36/37/39-22-222636/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)N
• Uses: 4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates. 4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.

Technology Process of 4-Amino-1-Boc-piperidine

There total 39 articles about 4-Amino-1-Boc-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate (150008-24-5) → 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7)

Guidance literature:

With hydrogen; Raney nickel; In ethanol; under 2585.81 Torr;

Reference yield: 98.0%

4-benzylamino-piperidine-1-carboxylic acid tert-butyl ester (206273-87-2) → 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; under 5320.36 Torr;

Reference yield: 97.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; With ammonium acetate; In methanol; at 20 ℃; for 0.166667h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.1c09779

upstream raw materials:

tert-butyl 4-(2,2,2-trifluoroacetamido)piperidine-1-carboxylate

tert-butyl 4-azidopiperidine-1-carboxylate

4-benzylamino-piperidine-1-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide

tert‐butyl 4‐((2‐nitrophenyl)amino)piperidine‐1‐carboxylate

N-(3-cyanophenyl)-N'-(1-(t-butoxycarbonyl)piperidin-4-yl)urea

4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine

Refernces

• 1、 -. "sEH Inhibitor or pharmaceutically acceptable composition thereof as well as preparation method and application thereof". . . Retrieved 2021/09/21.
• 2、 -. "PROCESSES AND COMPOUNDS FOR THE DECARBOXYLATIVE AMINATION OF REDOX-ACTIVE ESTERS WITH DIAZIRINES". Page/Page column 38. . Retrieved 2020/12/30.