Loteprednol

Base Information

• Chemical Name: Loteprednol
• CAS No.: 129260-79-3
• Molecular Formula: C21H27ClO5
• Molecular Weight: 394.89
• Hs Code.: 2937229000
• UNII: Z8CBU6KR16
• DSSTox Substance ID: DTXSID10156128
• Nikkaji Number: J561.829K
• Wikipedia: Loteprednol
• Wikidata: Q72487729
• NCI Thesaurus Code: C72818
• RXCUI: 237027
• Metabolomics Workbench ID: 43149
• Mol file: 129260-79-3.mol

Synonyms:17-ethoxycarbonyloxy-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate, Chloromethyl;Alrex;CEHOAC;Chloromethyl 17 ethoxycarbonyloxy 11 hydroxy 3 oxoandrosta 1,4 diene 17 carboxylate;chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate;Etabonate, Loteprednol;Lotemax;loteprednol;loteprednol etabonate

Chemical Property of Loteprednol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• Boiling Point: 531.168 °C at 760 mmHg
• Flash Point: 275.041 °C
• PSA: 83.83000
• Density: 1.34 g/cm³
• LogP: 2.73570
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 394.1547017
• Heavy Atom Count: 27
• Complexity: 745

Purity/Quality:

99% ^*data from raw suppliers

LOTEPREDNOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CC(C3C(C1CCC2(C(=O)OCCl)O)CCC4=CC(=O)C=CC34C)O
• Isomeric SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)OCCl)O)CCC4=CC(=O)C=C[C@]34C)O
• Recent ClinicalTrials: Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis
• Recent EU Clinical Trials: A multicenter, Investigator - masked, parallel-group, randomized study of the efficacy and safety of loteprednol etabonate 0.5% eyedrops versus dexamethasone 0.1% eyedrops in the treatment of ocular inflammation following cataract surgery.
• Uses: Antiinflammatory (topical).