Kornfeld ketone

Base Information

• Chemical Name: Kornfeld ketone
• CAS No.: 51867-02-8
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.323
• Mol file: 51867-02-8.mol

Synonyms:

Chemical Property of Kornfeld ketone

Chemical Property:

• PSA: 37.38000
• LogP: 3.47210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Kornfeld ketone

There total 5 articles about Kornfeld ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-benzoyl-3-(2-carboxyethyl)-2,3-dihydroindole → 1-benzoyl-2,2a,3,4-tetrahydro-1H-benz[cd]indol-5-one (132008-45-8,51867-02-8)

Guidance literature:

With PPA; at 100 ℃; for 2h;

DOI:10.1016/S0040-4020(01)80221-0

Reference yield:

3-(1-benzoyl-indolin-3-yl)-propionic acid (18749-79-6) → 1-benzoyl-2,2a,3,4-tetrahydro-1H-benz[cd]indol-5-one (132008-45-8,51867-02-8)

Guidance literature:

With thionyl chloride; Erwaermen des gebildeten Saeuerchlorids mit Aluminiumchlorid in Schwefelkohlenstoff;

DOI:10.1021/ja01594a039

Reference yield:

Indole-3-propionic acid (830-96-6) → 1-benzoyl-2,2a,3,4-tetrahydro-1H-benz[cd]indol-5-one (132008-45-8,51867-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; aqueous NaOH / 147102 - 220652 Torr / Hydrogenation_.Behandlung des Reaktionsprodukts mit Benzoylchlorid und wss. NaOH

2: thionyl chloride / Erwaermen des gebildeten Saeuerchlorids mit Aluminiumchlorid in Schwefelkohlenstoff

With sodium hydroxide; thionyl chloride; nickel;

DOI:10.1021/ja01594a039

upstream raw materials:

3-(1-benzoyl-indolin-3-yl)-propionic acid

thionyl chloride

Indole-3-propionic acid

Downstream raw materials:

1-benzoyl-1,2,2a,3,4,5-hexahydro-benz[cd]indol-5-ol

1-benzoyl-4-(2-oxopropyl)-2,2a,3,4-tetrahydrobenzindol-5(1H)-one

<(4-methylphenyl)sulfonyl>oxime of 1-benzoyl-2,2a,3,4-tetrahydrobenzindol-5(1H)-one

1-benzoyl-4-[methyl-(2-methyl-[1,3]dioxolan-2-ylmethyl)-amino]-2,2a,3,4-tetrahydro-1H-benz[cd]indol-5-one

Refernces