2-METHOXY-5-(TRIFLUOROMETHOXY)ANILINE

Base Information

• Chemical Name: 2-METHOXY-5-(TRIFLUOROMETHOXY)ANILINE
• CAS No.: 660848-57-7
• Molecular Formula: C8H8F3NO2
• Molecular Weight: 207.152
• Hs Code.: 2922299090
• Mol file: 660848-57-7.mol

Synonyms:2-Methoxy-5-trifluormethansulfonyl-anilin;2-methoxy-5-trifluoromethoxyaniline;2-methoxy-5-(trifluoromethane)sulfonylaniline;2-methoxy-5-(trifluoromethanesulfonyl)phenyl-amine;

Chemical Property of 2-METHOXY-5-(TRIFLUOROMETHOXY)ANILINE

Chemical Property:

• Refractive Index: 1.4762
• Boiling Point: 231.3±35.0 °C(Predicted)
• PKA: 3.31±0.10(Predicted)
• PSA: 44.48000
• Density: 1.326±0.06 g/cm3(Predicted)
• LogP: 2.75720

Purity/Quality:

99%, ^*data from raw suppliers

2-Methoxy-5-(trifluoromethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-5-(TRIFLUOROMETHOXY)ANILINE

There total 2 articles about 2-METHOXY-5-(TRIFLUOROMETHOXY)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-methoxy-2-nitro-4-(trifluoromethoxy)benzene (660848-54-4) → 2-methoxy-5-(trifluoromethoxy)aniline (660848-57-7)

Guidance literature:

With sodium dithionite; water; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

1-methoxy-4-(trifluoromethoxy)benzene (710-18-9) → 2-methoxy-5-(trifluoromethoxy)aniline (660848-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid

2: sodium dithionite

With sodium dithionite; sulfuric acid; nitric acid;

DOI:10.1021/acs.jmedchem.6b01903

Reference yield: 92.0%

2-methoxy-5-(trifluoromethoxy)aniline (660848-57-7) → C8H7BrF3NO2 (1359024-88-6)

Guidance literature:

With pyridinium hydrobromide perbromide; In dichloromethane; at 0 ℃; for 1h;

upstream raw materials:

1-methoxy-2-nitro-4-(trifluoromethoxy)benzene

1-methoxy-4-(trifluoromethoxy)benzene

Downstream raw materials:

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(2-methoxy-5-(trifluoromethyl)phenyl)butanamide Hydrochloride

C₈H₇BrF₃NO₂

C₈H₅BrF₃IO₂

C₉H₆BrF₃O₄

Refernces

• 1、 -. "TETRACYCLINE ANALOGS". Page/Page column 232. . Retrieved 2012/03/09.