4-METHOXYPHENYL TRIFLUOROMETHANESULFONATE

Base Information

• Chemical Name: 4-METHOXYPHENYL TRIFLUOROMETHANESULFONATE
• CAS No.: 66107-29-7
• Molecular Formula: C8H7F3O4S
• Molecular Weight: 256.202
• Hs Code.: 2909309090
• Mol file: 66107-29-7.mol

Synonyms:(4-methoxyphenyl) trifluoromethanesulfonate;

Chemical Property of 4-METHOXYPHENYL TRIFLUOROMETHANESULFONATE

Chemical Property:

• Vapor Pressure: 0.00526mmHg at 25°C
• Refractive Index: 1.454
• Boiling Point: 125oC/18mm
• Flash Point: 113oC
• PSA: 60.98000
• Density: 1.416
• LogP: 3.00440
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxyphenyl Trifluoromethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T
• Statements: 23/24/25-34-40
• Safety Statements: 23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methoxyphenyl trifluoromethanesulfonate is a useful research chemical.

Technology Process of 4-METHOXYPHENYL TRIFLUOROMETHANESULFONATE

There total 10 articles about 4-METHOXYPHENYL TRIFLUOROMETHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl triflate (66107-29-7)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/ja071268u

Reference yield: 92.0%

trifluorormethanesulfonic acid (1493-13-6) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl triflate (66107-29-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00313

Reference yield: 91.0%

4-methoxy-phenol (150-76-5) + (CF3SO2)2NC6H4-O-(PEG-3400)-OC6H4N(SO2CF3)2 → 4-methoxyphenyl triflate (66107-29-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1021/ol9913237

upstream raw materials:

trifluoromethylsulfonic anhydride

4-methoxy-phenol

para-nitrophenyl triflate

n-butyllithium

Downstream raw materials:

N,N-Diisopropyl-3-methoxyaniline

N,N-Diisopropyl-4-methoxyaniline

4-methoxylbiphenyl

4-methoxy-benzaldehyde

Refernces

• 1、 -. "C(sp3) -C(sp2) Method for constructing key and β - aryl amino acid preparation method". Paragraph 0037-0038; 0046. . Retrieved 2021/10/27.
• 2、 Wang, Zhen,Hu, Yuanyuan,Jin, Hongwei,Liu, Yunkui,Zhou, Bingwei. "Nickel-Catalyzed Arylation/Alkenylation of tert-Cyclobutanols with Aryl/Alkenyl Triflates via a C - C Bond Cleavage". . p. 466 - 474. Retrieved 2020/12/22.