Methanesulfonic acid, trifluoro-, 2-methylphenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 2-methylphenyl ester
• CAS No.: 66107-34-4
• Molecular Formula: C8H7F3O3S
• Molecular Weight: 240.203
• Mol file: 66107-34-4.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 2-methylphenyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 2-methylphenyl ester

There total 7 articles about Methanesulfonic acid, trifluoro-, 2-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoromethylsulfonic anhydride (358-23-6) + ortho-cresol (95-48-7,77504-84-8) → 2-methylphenyl triflate (66107-34-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1021/ja2066829

Reference yield: 95.0%

→ 2-methylphenyl triflate (66107-34-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃; for 5h; Inert atmosphere;

Reference yield: 94.0%

o-toluidine (95-53-4) + 1-ethyl-3-methylimidazolium triflate (145022-44-2) → 2-methylphenyl triflate (66107-34-4)

Guidance literature:

o-toluidine; 1-ethyl-3-methylimidazolium triflate; With tetrafluoroboric acid; sodium nitrite; at 0 - 20 ℃; for 12.5h;

at 70 ℃;

DOI:10.1016/S0022-1139(00)00337-7

upstream raw materials:

trifluorormethanesulfonic acid

2-methylphenyl diazonium tetrafluoroborate

trifluoromethylsulfonic anhydride

ortho-cresol

Downstream raw materials:

1-(1-Butoxy-vinyl)-2-methyl-benzene

N,N-diisopropyl(2-methylphenyl)amine

N,N-Diisopropyl-3-methylaniline

ortho-cresol

Refernces

• 1、 Zhu, Zhaodong,Gong, Yuxin,Tong, Weiqi,Xue, Weichao,Gong, Hegui. "Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Thiocarbonates via C-O/C-O Bond Cleavage". supporting information. p. 2158 - 2163. Retrieved 2021/04/05.
• 2、 Wang, Mingyue,Yang, Jia,Wang, Shuai,Zhong, Hong. "Base-promoted selective O-phosphorylation of aryl triflates with P(O)-H compounds". supporting information. . Retrieved 2020/05/05.