SEA-0400

Base Information

• Chemical Name: SEA-0400
• CAS No.: 223104-29-8
• Molecular Formula: C21H19 F2 N O3
• Molecular Weight: 371.3773
• Mol file: 223104-29-8.mol

Synonyms:SEA 0400

Chemical Property of SEA-0400

Chemical Property:

• Vapor Pressure: 1.46E-09mmHg at 25°C
• Boiling Point: 485°Cat760mmHg
• Flash Point: 247.1°C
• PSA: 53.71000
• Density: 1.254g/cm³
• LogP: 5.89820
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: insoluble in H2O; ≥18.57 mg/mL in DMSO; ≥46.4 mg/mL in EtOH with ultrasonic

Purity/Quality:

98%,99%, ^*data from raw suppliers

SEA0400 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively). It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson''s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.
• Uses: SEA 0400 is a novel and selective inhibitor of Na+-Ca2+ exchanger.