Palmitanilide

Base Information

• Chemical Name: Palmitanilide
• CAS No.: 6832-98-0
• Molecular Formula: C22H37 N O
• Molecular Weight: 331.542
• Hs Code.: 2924299090
• NSC Number: 57585
• DSSTox Substance ID: DTXSID60218467
• Nikkaji Number: J150.265D
• Wikidata: Q83095344
• ChEMBL ID: CHEMBL289007
• Mol file: 6832-98-0.mol

Synonyms:palmitanilide

Chemical Property of Palmitanilide

Chemical Property:

• Melting Point: 90 °C
• Refractive Index: 1.5614 (estimate)
• Boiling Point: 284 °C / 17mmHg
• Flash Point: 298.2oC
• PSA: 29.10000
• Density: 0.9770 (rough estimate)
• LogP: 7.17940
• XLogP3: 8.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 15
• Exact Mass: 331.287514804
• Heavy Atom Count: 24
• Complexity: 284

Purity/Quality:

98%,99%, ^*data from raw suppliers

Palmitanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)NC1=CC=CC=C1

Technology Process of Palmitanilide

There total 16 articles about Palmitanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

aniline (62-53-3) + 1-hexadecylcarboxylic acid (57-10-3) → palmitanilide (6832-98-0)

Guidance literature:

With trimethylamine borane; In xylene; for 7h; Heating;

DOI:10.1055/s-1983-30605

Reference yield: 94.0%

C28H40N2O2 (100663-86-3) + aniline (62-53-3) → palmitanilide (6832-98-0)

Guidance literature:

With copper dichloride; In dichloromethane; for 5.5h; Ambient temperature;

DOI:10.1246/cl.1985.701

Reference yield: 91.0%

1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one (74058-64-3) + aniline (62-53-3) → palmitanilide (6832-98-0)

Guidance literature:

In dichloromethane; for 95h; Ambient temperature;

DOI:10.1016/S0040-4039(00)71520-6

upstream raw materials:

palmitic acid azide

aniline

1-hexadecylcarboxylic acid

n-hexadecanoyl chloride

Downstream raw materials:

hexadecyl(phenyl)amine

2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide

C₃₇H₄₆N₂O₂

C₂₈H₄₂N₂

Refernces

• 1、 Nguyen, Thanh V. Q.,Yoo, Woo-Jin,Kobayashi, Shu. "Chelating Bis(1,2,3-triazol-5-ylidene) Rhodium Complexes: Versatile Catalysts for Hydrosilylation Reactions". supporting information. p. 452 - 458. Retrieved 2016/02/12.
• 2、 Ali,Siddiki,Onodera, Wataru,Kon, Kenichi,Shimizu, Ken-Ichi. "Amidation of Carboxylic Acids with Amines by Nb2O5 as a Reusable Lewis Acid Catalyst". . p. 3555 - 3561. Retrieved 2015/11/10.