2,4-Dichloro-5-aminopyrimidine

Base Information

• Chemical Name: 2,4-Dichloro-5-aminopyrimidine
• CAS No.: 5177-27-5
• Molecular Formula: C4H3Cl2N3
• Molecular Weight: 163.994
• Hs Code.: 29335990
• Mol file: 5177-27-5.mol

Synonyms:Pyrimidine,5-amino-2,4-dichloro- (6CI,7CI,8CI);2,4-Dichloropyrimidin-5-amine;5-Amino-2,4-dichloropyrimidine;NSC 86381;2,4-dichloropyrimidin-5-amine;2,4-Dichloro-5-pyrimidinamine;5-amino-2,4-dichloropyrimidine;Pyrimidine, 5-amino-2,4-dichloro-;5-Pyrimidinamine, 2,4-dichloro-;

Chemical Property of 2,4-Dichloro-5-aminopyrimidine

Chemical Property:

• Vapor Pressure: 0.00204mmHg at 25°C
• Melting Point: 108-112ºC
• Refractive Index: 1.633
• Boiling Point: 290.7 °C at 760 mmHg
• PKA: -1.55±0.29(Predicted)
• Flash Point: 129.6 °C
• PSA: 51.80000
• Density: 1.606 g/cm³
• LogP: 1.94680
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO, Methanol

Purity/Quality:

99.9% ^*data from raw suppliers

5-Amino-2,4-dichloropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A pyrimidinamine derivative as Plk1 inhibitors

Technology Process of 2,4-Dichloro-5-aminopyrimidine

There total 5 articles about 2,4-Dichloro-5-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4-Dichloro-5-nitropyrimidine (49845-33-2) → 5-amino-2,4-dichloropyrimidine (5177-27-5)

Guidance literature:

2,4-Dichloro-5-nitropyrimidine; With iron; acetic acid; for 14h;

With sodium carbonate; In water; ethyl acetate;

Reference yield: 11.0%

5-Aminouracil (932-52-5) → 5-amino-2,4-dichloropyrimidine (5177-27-5)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-aniline; trichlorophosphate;

Reference yield:

2,4-dichloro-5-nitropyridine (4487-56-3) → 5-amino-2,4-dichloropyrimidine (5177-27-5)

Guidance literature:

With iron; In acetic acid; at 23 - 50 ℃; for 1h;

upstream raw materials:

2,4-Dichloro-5-nitropyrimidine

5-Aminouracil

2,4-dichloro-5-nitropyridine

Downstream raw materials:

2,4-dimethoxypyrimidin-5-ylamine

4-ethylmercapto-2-chloro-pyrimidin-5-ylamine

pyrimidin-5-amine

5-chloro-2-phenyloxazolo[5,4-d]pyrimidine

Refernces

• 1、 -. "As tyrosine kinase inhibitors containing nitrogen and ring compound". Paragraph 0357; 0358; 0359; 0360. . Retrieved 2017/04/26.
• 2、 -. "Bicyclic Kinase Inhibitors". Page/Page column 17. . Retrieved 2011/08/22.