1H-Indole, 4-methyl-2-phenyl-

Base Information

• Chemical Name: 1H-Indole, 4-methyl-2-phenyl-
• CAS No.: 66354-67-4
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• Mol file: 66354-67-4.mol

Synonyms:4-methyl-2-phenyl-indole;2-Phenyl-4-methylindol;4-methyl-2-phenylindole;4-Methyl-2-phenyl-indol;1H-INDOLE, 4-METHYL-2-PHENYL-;

Chemical Property of 1H-Indole, 4-methyl-2-phenyl-

Chemical Property:

• PSA: 15.79000
• LogP: 4.14330

Purity/Quality:

98% ^*data from raw suppliers

1H-INDOLE,4-METHYL-2-PHENYL- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 4-methyl-2-phenyl-

There total 30 articles about 1H-Indole, 4-methyl-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-chloro-3-methylaniline (29027-17-6) + acetophenone (98-86-2) → 4-methyl-2-phenyl-1H-indole (66354-67-4)

Guidance literature:

With potassium phosphate; magnesium sulfate; acetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl acetamide; at 90 ℃; for 2h;

DOI:10.1002/anie.200460122

Reference yield: 81.0%

C15H13NO2 → 4-methyl-2-phenyl-1H-indole (66354-67-4)

Guidance literature:

With Triethoxysilane; C₂₅H₂₂FeNPS; In tetrahydrofuran; at 60 ℃; for 6h;

DOI:10.1021/acscatal.9b03604

Reference yield: 77.0%

2-(2,2-dibromovinyl)-3-methyl-phenylamine (863870-39-7) + phenylboronic acid (98-80-6) → 4-methyl-2-phenyl-1H-indole (66354-67-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate; In toluene; at 90 ℃; for 2h;

DOI:10.1021/ol051286l

upstream raw materials:

N-(2,3-dimethylphenyl)benzamide

2-(2,2-dibromovinyl)-3-methyl-phenylamine

phenylboronic acid

2-chloro-3-methylaniline

Refernces

• 1、 Delgado, Francisco,Gutiérrez, Rsuini U.,Hernández-Montes, Mayra,Mendieta-Moctezuma, Aarón,Tamariz, Joaquín. "Regioselective mercury(I)/palladium(II)-catalyzed single-step approach for the synthesis of imines and 2-substituted indoles". . . Retrieved 2021/07/21.
• 2、 Guan, Xinyu,Zhu, Haoran,Zhao, Yingwei,Driver, Tom G.. "Pd-Catalyzed Reductive Cyclization of Nitroarenes with CO2 as the CO Source". . p. 57 - 60. Retrieved 2019/12/11.