(2-AMINOETHYL)PHOSPHINIC ACID

Base Information

• Chemical Name: (2-AMINOETHYL)PHOSPHINIC ACID
• CAS No.: 85618-16-2
• Molecular Formula: C2H8 N O2 P
• Molecular Weight: 109.065
• Hs Code.: 2922499990
• Mol file: 85618-16-2.mol

Synonyms:(b-Aminoethyl)phosphinicacid; MP 105

Chemical Property of (2-AMINOETHYL)PHOSPHINIC ACID

Chemical Property:

• Melting Point: 208-210oC
• Boiling Point: 278oC
• Flash Point: 122oC
• PSA: 86.79000
• LogP: 0.11240

Purity/Quality:

99% ^*data from raw suppliers

(2-Aminoethyl)phosphinicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Aminoethylphosphonicacid is used in the preparation of phosphinothricin analogs which are potential inhibitors of glutamine synthetase.

Technology Process of (2-AMINOETHYL)PHOSPHINIC ACID

There total 3 articles about (2-AMINOETHYL)PHOSPHINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-aminoethyl-H-phosphinic acid hydrochloride (1075799-55-1) → 2-aminoethyl-H-phosphinic acid (85618-16-2)

Guidance literature:

With N-butylamine; In acetonitrile; for 12h; Reflux; Inert atmosphere;

DOI:10.1021/jo801768y

Reference yield:

2-carbamylethylphosphinic acid (95879-70-2) → 2-aminoethyl-H-phosphinic acid (85618-16-2)

Guidance literature:

With sodium hydroxide; bromine; In water; at -15 ℃;

DOI:10.1021/jm050474e

Reference yield:

(2-Amino-ethyl)-diethoxymethyl-phosphinic acid ethyl ester (125742-17-8) → 2-aminoethyl-H-phosphinic acid (85618-16-2)

Guidance literature:

With hydrogenchloride; for 4h; Yield given; Heating;

DOI:10.1016/S0040-4020(01)89240-1

upstream raw materials:

(2-Amino-ethyl)-diethoxymethyl-phosphinic acid ethyl ester

2-carbamylethylphosphinic acid

2-aminoethyl-H-phosphinic acid hydrochloride

Downstream raw materials:

(2-benzyloxycarbonylamino-ethyl)-H-phosphinic acid

Refernces

• 1、 Berlicki, ?ukasz,Obojska, Agnieszka,Forlani, Giuseppe,Kafarski, Pawel. "Design, synthesis, and activity of analogues of phosphinothricin as inhibitors of glutamine synthetase". . p. 6340 - 6349. Retrieved 2007/10/03.