Imidazo[1,2-b]pyridazin-6-amine

Base Information

• Chemical Name: Imidazo[1,2-b]pyridazin-6-amine
• CAS No.: 6653-96-9
• Molecular Formula: C6H6N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• European Community (EC) Number: 866-829-2
• DSSTox Substance ID: DTXSID50441303
• Wikidata: Q72482463
• Mol file: 6653-96-9.mol

Synonyms:Imidazo[1,2-b]pyridazin-6-amine;6653-96-9;6-Aminoimidazo[1,2-b]pyridazine;MFCD10698052;SCHEMBL1051267;DTXSID50441303;DCLWNTIANRACSB-UHFFFAOYSA-N;Imidazo[1,2-b]pyridazine-6-amine;AMY16386;BCP32518;AKOS006305345;AB61144;CS-W022760;GS-4241;4H-imidazo[2,1-f]pyridazin-6-yl-amine;2-AMINO-CHLOROBENZENEPHOSPHONICACID;FT-0648681;EN300-6409007;A853523;J-521508;Z1198278272

Chemical Property of Imidazo[1,2-b]pyridazin-6-amine

Chemical Property:

• Refractive Index: 1.774
• PSA: 56.21000
• Density: 1.509 g/cm³
• LogP: 0.89270
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 134.059246208
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

99%, ^*data from raw suppliers

Imidazo[1,2-b]pyridazin-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2N=C1N

Technology Process of Imidazo[1,2-b]pyridazin-6-amine

There total 4 articles about Imidazo[1,2-b]pyridazin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → 6-aminoimidazo[1,2-b]pyridazine (6653-96-9)

Guidance literature:

With ammonium hydroxide; at 180 ℃; for 8h;

DOI:10.7164/antibiotics.53.1053

Reference yield: 57.0%

C6H4ClN3*ClH (13493-79-3) → 6-aminoimidazo[1,2-b]pyridazine (6653-96-9)

Guidance literature:

With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C₅₀H₇₀NO₄PPdS; C₅₀H₇₀NO₄PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol401612c

Reference yield: 22.0%

6-azido-imidazo[1,2-b]pyridazine (13526-73-3) → 6-aminoimidazo[1,2-b]pyridazine (6653-96-9)

Guidance literature:

With Molybdenum(III) Reagent; In tetrahydrofuran; water; for 0.25h; Heating;

DOI:10.1055/s-1980-29225

upstream raw materials:

6-azido-imidazo[1,2-b]pyridazine

6-chloroimidazo[1,2-b]pyridazine

C₆H₄ClN₃*ClH

Downstream raw materials:

6-N'-methylureidoimidazo[1,2-b]pyridazine

3-(6-aminoimidazo[1,2-b]pyridazinium-1-yl)methyl-7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxymethoxyiminoacetamido]-3-cephem-4-carboxylate

6-ureidoimidazo[1,2-b]pyridazine

6-(phthalimidoacetyl)aminoimidazo[1,2-b]pyridazine

Refernces

• 1、 Ishikawa,Iizawa,Okonogi,Miyake. "Studies on Anti-MRSA parenteral cephalosporins I. Synthesis and antibacterial activity of 7". . p. 1053 - 1070. Retrieved 2007/10/03.
• 2、 Polanc, Slovenko,Stanovnik, Branko,Tisler, Miha. "Selective Reduction of Heterocyclic Azides and Hydrazino Compounds to Amines by Molybdenum(III) Species". . p. 830 - 831. Retrieved 2007/10/02.