2-Hydroxy-1-naphthylaldehyde benzoyl hydrazone

Base Information

• Chemical Name: 2-Hydroxy-1-naphthylaldehyde benzoyl hydrazone
• CAS No.: 15017-21-7
• Molecular Formula: C18H14 N2 O2
• Molecular Weight: 290.321
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID60933885
• Mol file: 15017-21-7.mol

Synonyms:2-hydroxy-1-naphthylaldehyde benzoyl hydrazone;HNB hydrazone

Chemical Property of 2-Hydroxy-1-naphthylaldehyde benzoyl hydrazone

Chemical Property:

• Vapor Pressure: 2.16E-09mmHg at 25°C
• Boiling Point: 480.5°Cat760mmHg
• Flash Point: 180.1°C
• PSA: 61.69000
• Density: 1.317g/cm³
• LogP: 3.70020
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 290.105527694
• Heavy Atom Count: 22
• Complexity: 404

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NN=CC2=C(C=CC3=CC=CC=C32)O

Technology Process of 2-Hydroxy-1-naphthylaldehyde benzoyl hydrazone

There total 5 articles about 2-Hydroxy-1-naphthylaldehyde benzoyl hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzoic acid hydrazide (613-94-5) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-hydroxynaphthaldehyde benzoyl hydrazone (15017-21-7)

Guidance literature:

In ethanol; for 4h; Inert atmosphere; Reflux;

DOI:10.1016/j.jorganchem.2012.08.002

Reference yield: 89.0%

benzoic acid hydrazide (613-94-5) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → [(E)‐N′‐((2‐hydroxynaphthalen‐1‐yl)methylene)benzohydrazide] (15017-21-7)

Guidance literature:

In ethanol; at 60 ℃; for 2h;

DOI:10.1016/j.saa.2015.12.004

Reference yield: 75.0%

Nicotinic acid hydrazide (553-53-7) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-hydroxynaphthaldehyde benzoyl hydrazone (15017-21-7)

Guidance literature:

In ethanol; for 0.5h; Reflux;

DOI:10.2174/1573406412666160225155908

upstream raw materials:

benzoic acid hydrazide

2-hydroxynaphthalene-1-carbaldehyde

Nicotinic acid hydrazide

benzoic acid methyl ester

Refernces

• 1、 Ji, Yuxiang,Yu, Chunwei,Wen, Shaobai,Zhang, Jun. "Characterization of an Al3+-selective fluorescent probe based on a benzoyl hydrazine derivative and its application in cell imaging". . p. 625 - 630. Retrieved 2016.
• 2、 Deng, Jungang,Wang, Jun,Khan, MuhammadHamid,Yu, Ping,Yang, Feng,Liang, Hong. "Structure and biological properties of five Pt(II) complexes as potential anticancer agents". . p. 10 - 16. Retrieved 2018.
• 3、 Kou, Xiaodi,Li, Xingying,Hu, Chengting,Liu, Juanjuan,Chen, Yuhong,Zhang, Yang,Yang, Aihong,Shen, Rui. "Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease". supporting information. . Retrieved 2021/11/18.
• 4、 Layek, Samaresh,Agrahari, Bhumika,Kumar, Akash,Dege, Necmi,Pathak, Devendra D.. "Synthesis and X-ray crystal structures of three new nickel(II) complexes of benzoylhydrazones: Catalytic applications in the synthesis of 2-arylbenzoxazoles". . . Retrieved 2019/11/11.