1H-IMidazole, 2-(trifluor...

Base Information

• Chemical Name: 1H-IMidazole, 2-(trifluor...
• CAS No.: 66675-22-7
• Molecular Formula: C4H3F3N2
• Molecular Weight: 136.076
• Hs Code.: 2933299090
• Mol file: 66675-22-7.mol

Synonyms:2-Trifluormethylimidazol;1H-Imidazole,2-(trifluoromethyl);2-trifluoromethyl-1H-imidazole;Imidazole,2-trifluoromethyl;2-(trifluoromethyl)imidazole;

Chemical Property of 1H-IMidazole, 2-(trifluor...

Chemical Property:

• Melting Point: 145-147 °C(Solv: chloroform (67-66-3))
• Boiling Point: 186.1±40.0 °C(Predicted)
• PKA: 10.65±0.10(Predicted)
• PSA: 28.68000
• Density: 1.440±0.06 g/cm3(Predicted)
• LogP: 1.42850
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Trifluoromethylimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Trifluoromethylimidazole is an intermediate used to prepare sulfonamide derivatives as amyloid β prodn. inhibitors useful in treating or preventing diseases related to Aβ.

Technology Process of 1H-IMidazole, 2-(trifluor...

There total 9 articles about 1H-IMidazole, 2-(trifluor... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1H-imidazole-2-carboxylic acid (16042-25-4) → 2-(trifluoromethyl)imidazole (66675-22-7)

Guidance literature:

With sulfur tetrafluoride; hydrogen fluoride; at 70 ℃; for 48h;

DOI:10.1016/S0022-1139(00)85263-X

Reference yield: 32.0%

1H-imidazole (288-32-4) + iodotrifluoromethane (2314-97-8,263005-66-9) → 4-(trifluoromethyl)-1H-imidazole (33468-69-8) + 2-(trifluoromethyl)imidazole (66675-22-7)

Guidance literature:

In methanol; for 168h; Ambient temperature; Irradiation;

DOI:10.1021/jo00136a010

Reference yield: 32.0%

1H-imidazole (288-32-4) + iodotrifluoromethane (2314-97-8,263005-66-9) → 2,4-bis(trifluoromethyl)-1H-imidazole (81654-07-1) + 4-(trifluoromethyl)-1H-imidazole (33468-69-8) + 2-(trifluoromethyl)imidazole (66675-22-7)

Guidance literature:

In methanol; for 168h; Product distribution; Mechanism; Ambient temperature; Irradiation; var. perfluoroalkyl iodides; other imidazoles;

DOI:10.1021/jo00136a010

upstream raw materials:

1H-imidazole

Bromotrifluoromethane

iodotrifluoromethane

difluorodiiodomethane

Refernces

• 1、 -. "Novel imidazole compounds, and preparation method and application thereof in medicine". Paragraph 0018; 0019. . Retrieved 2018/02/04.
• 2、 Chen, Qing-Yun,Li, Zhan-Ting. "Photoinduced Electron-transfer Reaction of Difluorodiiodomethane with Azaaromatic Compounds and Enamines". . p. 645 - 648. Retrieved 2007/10/02.