2-(4-Bromophenyl)-1-(4-methoxyphenyl) ethanone

Base Information

• Chemical Name: 2-(4-Bromophenyl)-1-(4-methoxyphenyl) ethanone
• CAS No.: 67205-73-6
• Molecular Formula: C15H13BrO2
• Molecular Weight: 305.171
• DSSTox Substance ID: DTXSID70474355
• Nikkaji Number: J2.336.626F
• Wikidata: Q82304334
• Mol file: 67205-73-6.mol

Synonyms:67205-73-6;2-(4-bromophenyl)-1-(4-methoxyphenyl) ethanone;2-(4-bromophenyl)-1-(4-methoxyphenyl)ethanone;Ethanone, 2-(4-bromophenyl)-1-(4-methoxyphenyl)-;2-(4-Bromophenyl)-1-(4-methoxyphenyl)ethan-1-one;SCHEMBL7854504;DTXSID70474355;LJSXRFCPUUXZBC-UHFFFAOYSA-N;2-(4-Bromo-phenyl)-1-(4-methoxy-phenyl)-ethanone

Chemical Property of 2-(4-Bromophenyl)-1-(4-methoxyphenyl) ethanone

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 304.00989
• Heavy Atom Count: 18
• Complexity: 264

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)CC2=CC=C(C=C2)Br

Technology Process of 2-(4-Bromophenyl)-1-(4-methoxyphenyl) ethanone

There total 6 articles about 2-(4-Bromophenyl)-1-(4-methoxyphenyl) ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-bromo-4-[2-(4-methoxyphenyl)ethynyl]benzene (189099-57-8) → 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone (67205-73-6)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 120 ℃; for 1h; microwave irradiation;

DOI:10.1016/j.tetlet.2006.05.155

Reference yield: 87.0%

methoxybenzene (100-66-3) + 2-(4-bromophenyl)-acetic acid (1878-68-8) → 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone (67205-73-6)

Guidance literature:

2-(4-bromophenyl)-acetic acid; With thionyl chloride; for 3h; Heating;

methoxybenzene; With aluminium trichloride; In dichloromethane; for 2h; Further stages.; Heating;

DOI:10.1016/j.tet.2007.05.032

Reference yield: 85.0%

2-(4-bromophenyl)acetyl chloride (37859-24-8) + methoxybenzene (100-66-3) → 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone (67205-73-6)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2015.02.019

upstream raw materials:

2-(4-bromophenyl)acetyl chloride

methoxybenzene

2-(4-bromophenyl)-acetic acid

1-bromo-4-[2-(4-methoxyphenyl)ethynyl]benzene

Downstream raw materials:

2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-butanone

2-(4-bromophenyl)-1-(4-hydroxyphenyl) ethanone

4-[2-(4-Bromo-phenyl)-ethyl]-phenol

1-(4-methoxyphenyl)-2-(4-bromophenyl)-3-(3-methoxyphenyl)-1-propanone

Refernces

• 1、 Yu, Jing-Wen,Mao, Shuai,Wang, Yong-Qiang. "Copper-catalyzed base-accelerated direct oxidation of C-H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant". . p. 1575 - 1580. Retrieved 2015/03/14.
• 2、 Kuo, Wen-Jang,Chen, Ying-Hsiao,Jeng, Ru-Jong,Chan, Li-Hsin,Lin, Wen-Peng,Yang, Zhe-Ming. "Peripheral aryl-substituted pyrrole fluorophores for glassy blue-light-emitting diodes". . p. 7086 - 7096. Retrieved 2008/02/09.