Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride

Base Information

• Chemical Name: Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride
• CAS No.: 67469-45-8
• Molecular Formula: C28H30F2N2O.2ClH
• Molecular Weight: 521.478
• Mol file: 67469-45-8.mol

Synonyms:

Chemical Property of Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride

There total 2 articles about Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

trans-1-cinnamylpiperazine (18903-01-0,114312-65-1,87179-40-6) + 2-[bis(4-fluorophenyl)methoxy]ethyl chloride (50366-31-9) → GBR 13069 dihydrochloride (67469-45-8)

Guidance literature:

With hydrogenchloride; potassium carbonate; potassium iodide; In various solvent(s); for 24h; Heating;

Reference yield:

4,4'-difluorobenzhydryl alcohol (365-24-2) → GBR 13069 dihydrochloride (67469-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / conc. sulphuric acid / toluene / 5 h / Heating

2: 53 percent / 1.) potassium carbonate, potassium iodide, 2.) hydrochloric acid / various solvent(s) / 24 h / Heating

With hydrogenchloride; sulfuric acid; potassium carbonate; potassium iodide; In toluene;

Reference yield: 80.0%

methyl bromide (74-83-9) + GBR 13069 dihydrochloride (67469-45-8) → 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-((E)-3-phenyl-allyl)-piperazine; compound with bromomethane

Guidance literature:

In acetone; Heating;

upstream raw materials:

trans-1-cinnamylpiperazine

2-[bis(4-fluorophenyl)methoxy]ethyl chloride

4,4'-difluorobenzhydryl alcohol

Refernces