4-Methyl-2-nonanone

Base Information

• Chemical Name: 4-Methyl-2-nonanone
• CAS No.: 67639-92-3
• Molecular Formula: C10H20O
• Molecular Weight: 156.26500
• Mol file: 67639-92-3.mol

Synonyms:

Chemical Property of 4-Methyl-2-nonanone

Chemical Property:

• Melting Point: -3.45°C (estimate)
• Refractive Index: 1.4235 (estimate)
• Boiling Point: 205.54°C (estimate)
• PSA: 17.07000
• Density: 0.8284 (estimate)
• LogP: 3.18190

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-nonan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-2-nonanone

There total 11 articles about 4-Methyl-2-nonanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-non-3-en-2-one (18402-83-0) + trimethylaluminum (75-24-1) → 4-methyl-2-nonanone (67639-92-3)

Guidance literature:

copper(I) bromide; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1016/0040-4020(94)00975-Z

Reference yield: 85.0%

Non-3-en-2-on (14309-57-0) + methyl manganese chloride (89984-56-5) → 4-methyl-2-nonanone (67639-92-3)

Guidance literature:

With copper(l) chloride; In tetrahydrofuran; at 0 ℃;

DOI:10.15227/orgsyn.072.0135

Reference yield: 81.0%

(E)-non-3-en-2-one (18402-83-0) + methylmagnesium bromide (75-16-1) → 4-methyl-2-nonanone (67639-92-3)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; O-mono(N,N-dimethyl thiourea)substituted BINOL; In tetrahydrofuran; at -20 ℃; for 0.333333h;

DOI:10.1016/S0040-4039(98)02686-0

upstream raw materials:

methyl magnesium iodide

3-methyl-octanenitrile

2-bromoheptane

sodium ethyl acetylacetate enolate

Refernces

• 1、 Lorenzo, Paula,Aurrecoechea, Jose M.,De Lera, Angel R.,Alvarez, Rosana. "Palladium-catalyzed diorganozinc conjugate additions to enones: Preparative and computational studies". . p. 2621 - 2626. Retrieved 2013/06/04.
• 2、 Bennett, Simon M.W.,Brown, Stephen M.,Muxworthy, James P.,Woodward, Simon. "Copper-catalysed asymmetric conjugate addition of organometallic reagents to linear enones using thiourethane ligands". . p. 1767 - 1770. Retrieved 2007/10/03.