2,4-Dichloro-6-(methylamino)-1,3,5-triazine

Base Information

• Chemical Name: 2,4-Dichloro-6-(methylamino)-1,3,5-triazine
• CAS No.: 27282-80-0
• Molecular Formula: C4H4 Cl2 N4
• Molecular Weight: 179.009
• Hs Code.: 2933699090
• Mol file: 27282-80-0.mol

Synonyms:s-Triazine, 2,4-dichloro-6-(methylamino)-(6CI,7CI,8CI); 2,4-Dichloro-6-(methylamino)-1,3,5-triazine;2,4-Dichloro-6-(methylamino)-s-triazine;2-Methylamino-4,6-dichloro-s-triazine;4,6-Dichloro-2-methylamino-1,3,5-triazine;4,6-Dichloro-N-methyl-1,3,5-triazin-2-amine; N-Methylaminodichloro-s-triazine;NSC 221222

Chemical Property of 2,4-Dichloro-6-(methylamino)-1,3,5-triazine

Chemical Property:

• Vapor Pressure: 2.27E-05mmHg at 25°C
• Boiling Point: 360.1°Cat760mmHg
• Flash Point: 171.6°C
• PSA: 50.70000
• Density: 1.591g/cm³
• LogP: 1.29310

Purity/Quality:

99% ^*data from raw suppliers

4,6-dichloro-N-methyl-1,3,5-triazin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-6-(methylamino)-1,3,5-triazine

There total 4 articles about 2,4-Dichloro-6-(methylamino)-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + methylamine hydrochloride (593-51-1) → 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine (27282-80-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -70 - 20 ℃; for 3h;

Reference yield: 97.0%

methylamine hydrochloride (593-51-1) + 2,4-dihydroxy-6-chloro-1,3,5-triazine (69125-10-6) → 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine (27282-80-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -70 - 20 ℃; for 3h;

Reference yield: 76.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + methylamine (74-89-5) → 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine (27282-80-0)

Guidance literature:

With sodium carbonate; In water; acetone; at -10 ℃;

DOI:10.1016/j.tet.2012.09.103

upstream raw materials:

1,3,5-trichloro-2,4,6-triazine

methylamine

methylamine hydrochloride

2,4-dihydroxy-6-chloro-1,3,5-triazine

Downstream raw materials:

(bis-aziridin-1-yl-[1,3,5]triazin-2-yl)-methyl-amine

N-[2-(4-Chloro-6-methylamino-[1,3,5]triazin-2-ylamino)-ethyl]-benzamide

2-chloro-4-methylamino-6-phenylamino-1,3,5-triazine

Refernces

• 1、 Lee, Sujin,Phuan, Puay-Wah,Felix, Christian M.,Tan, Joseph-Anthony,Levin, Marc H.,Verkman, Alan S.. "Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases". . p. 1210 - 1218. Retrieved 2017.
• 2、 Alvani, Mohsen,Asadi, Parvin,Hajhashemi, Valiollah,Khodarahmi, Ghadamali,Rostami, Mahboubeh. "Design, synthesis, biological evaluation, and molecular docking study on triazine based derivatives as anti-inflammatory agents". . . Retrieved 2021/07/01.
• 3、 Yu, Xufen,Huang, Xi-Ping,Kenakin, Terry P.,Slocum, Samuel T.,Chen, Xin,Martini, Michael L.,Liu, Jing,Jin, Jian. "Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)". . p. 7557 - 7574. Retrieved 2019/09/09.