2,6-Dimethylpyridin-4-amine

Base Information

• Chemical Name: 2,6-Dimethylpyridin-4-amine
• CAS No.: 3512-80-9
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 29333990
• European Community (EC) Number: 222-515-1
• NSC Number: 5090
• UNII: HJD75C9L2X
• DSSTox Substance ID: DTXSID10188621
• Nikkaji Number: J41.169H
• Wikidata: Q72471826
• Mol file: 3512-80-9.mol

Synonyms:3512-80-9;2,6-Dimethylpyridin-4-amine;4-Amino-2,6-dimethylpyridine;2,6-DIMETHYL-PYRIDIN-4-YLAMINE;2,6-dimethylpyridin-4-ylamine;4-Amino-2,6-lutidine;4-Pyridinamine, 2,6-dimethyl-;2,6-Dimethylpyridin-4yl-amine;MFCD00130078;HJD75C9L2X;NSC-5090;EINECS 222-515-1;2,6-DIMETHYL-4-AMINOPYRIDINE;NSC5090;4-amino-2, 6-lutidine;UNII-HJD75C9L2X;SCHEMBL589612;2,6-Dimethyl-4-pyridinamine #;DTXSID10188621;2,6-LUTIDINE, 4-AMINO-;CS-D0789;NSC 5090;BBL103867;STL557677;AKOS006345939;AB03678;PS-3875;SB36772;AC-22344;BL000684;SY009428;4-Amino-2,6-dimethylpyridine, AldrichCPR;AM20061837;FT-0649125;EN300-89439;A822588;AC-907/34119009;J-507522;Z1201619217;2,6-dimethylpyridin-4-amine

Chemical Property of 2,6-Dimethylpyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.027mmHg at 25°C
• Melting Point: 191.0 to 195.0 °C
• Refractive Index: 1.564
• Boiling Point: 246.806 °C at 760 mmHg
• PKA: 10.30±0.50(Predicted)
• Flash Point: 126.457 °C
• PSA: 38.91000
• Density: 1.04 g/cm³
• LogP: 1.86180
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 82.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Dimethylpyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)C)N
• Uses: 4-Amino-2,6-dimethylpyridine, is an important raw material and intermediate used in pharmaceuticals, agrochemicals, dyestuff, field.

Technology Process of 2,6-Dimethylpyridin-4-amine

There total 10 articles about 2,6-Dimethylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-nitro-2,6-lutidine-1-oxide (4808-64-4) → 4-amino-2,6-lutidine (3512-80-9)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 50 ℃; for 19h; under 2327.2 Torr;

DOI:10.1002/jhet.5570340303

Reference yield: 5.0%

2,6-dimethylpyridine (108-48-5) → 4-amino-2,6-lutidine (3512-80-9)

Guidance literature:

With sodium amide; at 140 - 150 ℃;

DOI:10.1002/jhet.5570340303

Reference yield:

4-nitro-2,6-dimethylpyridine (4913-57-9) → 4-amino-2,6-lutidine (3512-80-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol;

upstream raw materials:

2,6-dimethylpyridine

4-chloro-2,6-lutidine

4-nitro-2,6-lutidine-1-oxide

toluene

Downstream raw materials:

4-chloro-2,6-lutidine

4-bromo-2,6-dimethylpyridine

4-iodo-2,6-dimethylpyridine

3-bromo-4-amino-2,6-dimethylpyridine

Refernces

• 1、 -. "A 2, 6 - dimethyl -4 - bromo pyridine synthesis method". Paragraph 0011; 0013; 0015; 0017; 0019; 0021. . Retrieved 2019/05/28.
• 2、 -. "NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS". Page/Page column 59; 60. . Retrieved 2008/06/13.