1H-Indazole-3-carboxaldehyde, 4,6-dinitro-1-phenyl-, oxime

Base Information

• Chemical Name: 1H-Indazole-3-carboxaldehyde, 4,6-dinitro-1-phenyl-, oxime
• CAS No.: 681001-62-7
• Molecular Formula: C14H9N5O5
• Molecular Weight: 327.256
• Mol file: 681001-62-7.mol

Synonyms:

Chemical Property of 1H-Indazole-3-carboxaldehyde, 4,6-dinitro-1-phenyl-, oxime

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indazole-3-carboxaldehyde, 4,6-dinitro-1-phenyl-, oxime

There total 4 articles about 1H-Indazole-3-carboxaldehyde, 4,6-dinitro-1-phenyl-, oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-formyl-4,6-dinitro-1-phenyl-1H-indazole (544676-41-7) → 4,6-dinitro-1-phenyl-1H-indazole-3-carboxaldehyde oxime (681001-62-7)

Guidance literature:

With hydroxylamine hydrochloride; acetic acid; for 6h; Heating;

DOI:10.1023/A:1026008821698

Reference yield:

picrylacetaldehyde → 4,6-dinitro-1-phenyl-1H-indazole-3-carboxaldehyde oxime (681001-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 79 percent / NaNO₂; HCl; AcONa / H₂O; ethanol / 1 h / 0 - 5 °C / pH 5

2: K₂CO₃ / 24 h / 20 °C

3: 8 h / 80 °C

4: 76 percent / NH₂OH*HCl; acetic acid / 6 h / Heating

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water;

DOI:10.1023/A:1026008821698

Reference yield:

2-(2-phenylhydrazono)-2-(2,4,6-trinitrophenyl)acetaldehyde → 4,6-dinitro-1-phenyl-1H-indazole-3-carboxaldehyde oxime (681001-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / 24 h / 20 °C

2: 8 h / 80 °C

3: 76 percent / NH₂OH*HCl; acetic acid / 6 h / Heating

With hydroxylamine hydrochloride; potassium carbonate; acetic acid;

DOI:10.1023/A:1026008821698

upstream raw materials:

3-formyl-4,6-dinitro-1-phenyl-1H-indazole

(4,6-dinitro-1-phenyl-1H-indazol-3-yl)(ethoxy)methanol

Downstream raw materials:

3-cyano-4,6-dinitro-1-phenyl-1H-indazole

methyl 2-[(3-cyano-6-nitro-1-phenyl-1H-indazol-4-yl)thio]acetic acid

3-cyano-6-nitro-1-phenyl-4-phenylthio-1H-indazole

Refernces