2-(Trifluoromethoxy)phenyl isocyanate

Base Information

• Chemical Name: 2-(Trifluoromethoxy)phenyl isocyanate
• CAS No.: 182500-26-1
• Molecular Formula: C8H4F3NO2
• Molecular Weight: 203.12
• Hs Code.: 29291090
• Mol file: 182500-26-1.mol

Synonyms:1-Isocyanato-2-(trifluoromethoxy)benzene;2-Trifluoromethoxyphenyl isocyanate;

Chemical Property of 2-(Trifluoromethoxy)phenyl isocyanate

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 0.803mmHg at 25°C
• Refractive Index: n20/D 1.455(lit.)
• Boiling Point: 182.6 °C at 760 mmHg
• Flash Point: 60 °C
• PSA: 38.66000
• Density: 1.3 g/cm³
• LogP: 2.55250
• Storage Temp.: 0-6°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

98% ^*data from raw suppliers

2-(Trifluoromethoxy)phenyl Isocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, F, Xn
• Hazard Codes: T,F,Xn
• Statements: 25-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Trifluoromethoxyphenyl Isocyanate is a reactant used in the synthesis and characterization of novel pyrazole-4-carboxamide derivatives displaying nematocidal activity.

Technology Process of 2-(Trifluoromethoxy)phenyl isocyanate

There total 1 articles about 2-(Trifluoromethoxy)phenyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(trifluoromethoxy)phenyl isocyanate (182500-26-1)

Guidance literature:

Reference yield: 96.0%

2-(trifluoromethoxy)phenyl isocyanate (182500-26-1) + (6R)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol (187235-13-8) → (6R)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl [2-(trifluoromethoxy)phenyl]carbamate

Guidance literature:

With copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 43h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01581

Reference yield: 91.0%

2-(trifluoromethoxy)phenyl isocyanate (182500-26-1) + 3-(difluoromethyl)-N-(1-hydroxypropan-2-yl)-1-methyl-1H-pyrazole-4-carboxamide (1105713-22-1) → 2-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)propyl (2-(trifluoromethoxy)phenyl)carbamate

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.ejmech.2016.10.017

Downstream raw materials:

(5S,11aS)-5-(3-hydroxyphenyl)-2-[2-(trifluoromethoxy)phenyl]-6H-1,2,3,5,11,11a-hexahydro-imidazo[1,5-b]-β-carboline-1,3-dione

4-{4-[benzenesulfonyl-(3H-imidazol-4-ylmethyl)amino]phenyl}-piperazine-1-carboxylic acid (2-trifluoromethoxyphenyl)amide

N-[4-(3-amino-1,2-benzisoxazol-4-yl)phenyl]-N'-[2-(trifluoromethoxy)phenyl]urea

N-(2-trifluoromethoxyphenyl)-3-(([(2-trifluoromethoxyphenyl)amino]carbonyl)amino)-1H-indazole-1-carboxamide

Refernces

• 1、 -. "Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors". . . Retrieved 2008/06/13.