(3-BroMo-4-Methylphenyl)Methanol

Base Information

• Chemical Name: (3-BroMo-4-Methylphenyl)Methanol
• CAS No.: 68120-35-4
• Molecular Formula: C8H9BrO
• Molecular Weight: 201.063
• Hs Code.: 2906299090
• Mol file: 68120-35-4.mol

Synonyms:Benzenemethanol,3-bromo-4-methyl;3-bromo-4-methylbenzyl alcohol;

Chemical Property of (3-BroMo-4-Methylphenyl)Methanol

Chemical Property:

• Melting Point: 38-42°C
• Boiling Point: 283.4±25.0 °C(Predicted)
• PKA: 14.29±0.10(Predicted)
• Flash Point: >110℃
• PSA: 20.23000
• Density: 1.481±0.06 g/cm3(Predicted)
• LogP: 2.24980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3-Bromo-4-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-BroMo-4-Methylphenyl)Methanol

There total 3 articles about (3-BroMo-4-Methylphenyl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-bromo-4-methylbenzoic acid (7697-26-9) → (3-bromo-4-methyl-phenyl)-methanol (68120-35-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm4008517

Reference yield: 49.6%

3-bromo-4-methyl-benzaldehyde (36276-24-1) → (3-bromo-4-methyl-phenyl)-methanol (68120-35-4)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 2h;

Reference yield:

4-methyl-benzaldehyde (104-87-0) → (3-bromo-4-methyl-phenyl)-methanol (68120-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 40 °C

1.2: 0 - 20 °C

2.1: methanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; In dichloromethane;

upstream raw materials:

3-bromo-4-methylbenzoic acid

3-bromo-4-methyl-benzaldehyde

4-methyl-benzaldehyde

Downstream raw materials:

5-Hydroxymethyl-2-methyl-benzoic acid ethyl ester

3-bromo-4-methyl-benzaldehyde

5-(hydroxymethyl)-2-methylbenzoic acid

1,3-bis(3-bromo-4-methylphenyl)urea

Refernces

• 1、 -. "ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS". Page/Page column 66. . Retrieved 2015/07/07.
• 2、 -. "ANTIDIABETIC TRICYCLIC COMPOUNDS". Page/Page column 122. . Retrieved 2014/02/16.