Benzenepropanoic acid, b-(phenylamino)-, ethyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, b-(phenylamino)-, ethyl ester
• CAS No.: 6846-55-5
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 6846-55-5.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, b-(phenylamino)-, ethyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, b-(phenylamino)-, ethyl ester

There total 18 articles about Benzenepropanoic acid, b-(phenylamino)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl bromoacetate (105-36-2) + (E)-N-benzylidenebenzenamine (1750-36-3,33993-35-0,538-51-2,137431-97-1,137432-04-3) → ethyl 3-anilino-3-phenylpropanoate (6846-55-5,870998-80-4)

Guidance literature:

With indium; at 20 ℃; for 5h;

DOI:10.1055/s-2007-990799

Reference yield: 80.0%

ethyl acetate (141-78-6) + (E)-N-benzylidenebenzenamine (1750-36-3,33993-35-0,538-51-2,137431-97-1,137432-04-3) → ethyl 3-anilino-3-phenylpropanoate (6846-55-5,870998-80-4)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; Inert atmosphere;

DOI:10.1002/ejoc.201500958

Reference yield: 75.0%

ethyl (2Z)-3-phenyl-3-(phenylamino)prop-2-enoate (3556-76-1,124413-92-9,53256-22-7) → ethyl 3-anilino-3-phenylpropanoate (6846-55-5,870998-80-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetic acid; for 2h; Ambient temperature;

DOI:10.1021/jo00097a039

upstream raw materials:

Diazoethan

3-bromo-3-phenylpropionic acid

aniline

ethanol

Downstream raw materials:

N-phenyl-N-(1-phenylpent-3-yn-1-yl)pentanamide

5-methyl-6-oxo-1,2-diphenyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

ethyl (RS)-3-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}-3-phenylpropionate

1-anilino-1-phenyl-heptan-3-one

Refernces

• 1、 Wade Downey,Ingersoll, Jared A.,Glist, Hadleigh M.,Dombrowski, Carolyn M.,Barnett, Adam T.. "One-Pot Silyl Ketene Acetal-Formation Mukaiyama-Mannich Additions to Imines Mediated by Trimethylsilyl Trifluoromethanesulfonate". supporting information. p. 7287 - 7291. Retrieved 2015/11/25.
• 2、 Mrsic, Natasa,Panella, Lavinia,Minnaard, Adriaan J.,Feringa, Ben L.,De Vries, Johannes G.. "Synthesis of N-phenyl β-amino acids via iridium-catalyzed asymmetric hydrogenation using mixed monodentate ligands". scheme or table. p. 36 - 39. Retrieved 2011/04/18.