1,3,4-Oxadiazole-2-carboxamide, 5-phenyl-

Base Information

• Chemical Name: 1,3,4-Oxadiazole-2-carboxamide, 5-phenyl-
• CAS No.: 68496-74-2
• Molecular Formula: C9H7N3O2
• Molecular Weight: 189.17100
• Hs Code.: 2934999090
• Mol file: 68496-74-2.mol

Synonyms:5-Phenyl-[1,3,4]oxadiazole-2-carboxylic acid amide;5-phenyl-1,3,4-oxadiazole-2-carboxamide;5-Phenyl-1,3,4-oxadiazol-carbonsaeure-(2)-amid;2-Carbamyl-5-phenyl-1,3,4-oxadiazol;

Chemical Property of 1,3,4-Oxadiazole-2-carboxamide, 5-phenyl-

Chemical Property:

• Melting Point: 174.5 - 176 °C (H2O)
• PSA: 82.01000
• LogP: 1.53580

Purity/Quality:

99% ^*data from raw suppliers

5-Phenyl-1,3,4-oxadiazole-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,4-Oxadiazole-2-carboxamide, 5-phenyl-

There total 6 articles about 1,3,4-Oxadiazole-2-carboxamide, 5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

oxalamic acid-(N'-benzoyl-hydrazide) (4740-44-7) → 5-phenyl-[1,3,4]oxadiazole-2-carboxylic acid amide (68496-74-2)

Guidance literature:

With thionyl chloride; In 1,4-dioxane; for 1h; Heating;

Reference yield: 95.0%

ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate (16691-25-1) → 5-phenyl-[1,3,4]oxadiazole-2-carboxylic acid amide (68496-74-2)

Guidance literature:

With ammonia; In methanol; diethyl ether; Ambient temperature;

Reference yield:

benzoyl chloride (98-88-4) → 5-phenyl-[1,3,4]oxadiazole-2-carboxylic acid amide (68496-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / NaHCO₃ / dioxane / 10 h / 45 - 50 °C

2: 96 percent / NH₃ / methanol / Ambient temperature

3: 98 percent / SOCl₂ / dioxane / 1 h / Heating

With thionyl chloride; ammonia; sodium hydrogencarbonate; In 1,4-dioxane; methanol;

upstream raw materials:

N'-benzoyl-2-nitrilo-acetohydrazonic acid amide

oxalamic acid-(N'-benzoyl-hydrazide)

ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate

benzoyl chloride

Refernces