N-Hexyltrifluoroacetamide

Base Information

• Chemical Name: N-Hexyltrifluoroacetamide
• CAS No.: 687-09-2
• Molecular Formula: C8H14F3NO
• Molecular Weight: 197.2
• Hs Code.: 2924199090
• Mol file: 687-09-2.mol

Synonyms:N-n-hexyltrifluoroacetamide;Trifluor-essigsaeure-hexylamid;Acetamide,2,2,2-trifluoro-n-hexyl;trifluoro-acetic acid hexylamide;2,2,2-Trifluor-N-hexyl-acetamid;N-n-Hexyl-trifluoracetamid;N-Hexyltrifluoracetamid;

Chemical Property of N-Hexyltrifluoroacetamide

Chemical Property:

• PSA: 32.59000
• LogP: 3.08550

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Hexyltrifluoroacetamide

There total 8 articles about N-Hexyltrifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

hexan-1-amine (111-26-2) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-hexylacetamide (687-09-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c01385

Reference yield: 95.0%

trifluoroacetic anhydride (407-25-0) + 2-hex-1-yl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (86308-26-1) → 2,2,2-trifluoro-N-hexylacetamide (687-09-2)

Guidance literature:

2-hex-1-yl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; With potassium tert-butylate; 1-amino-1,4-diazabicyclo[2.2.2]octane-1,4-diium iodide; In tetrahydrofuran; at 80 ℃; for 1h; Sealed tube;

trifluoroacetic anhydride; In tetrahydrofuran; at 80 ℃; for 1h; Sealed tube;

DOI:10.1002/anie.201913388

Reference yield: 95.0%

hexan-1-amine (111-26-2) + 2-(trifluoroacetyloxy)pyridine (96254-05-6) → 2,2,2-trifluoro-N-hexylacetamide (687-09-2)

Guidance literature:

In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1246/bcsj.63.2252

upstream raw materials:

hexan-1-amine

trifluoroacetic anhydride

2-(trifluoroacetyloxy)pyridine

triphenylantimony bis(trifluoroacetate)

Downstream raw materials:

hexan-1-amine

2,2,2-trifluoroethanol

Refernces

• 1、 Hu, Qu-Ping,Cheng, Jing,Wang, Ying,Shi, Jie,Wang, Bi-Qin,Hu, Ping,Zhao, Ke-Qing,Pan, Fei. "Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes". supporting information. p. 4457 - 4462. Retrieved 2021/05/26.
• 2、 -. "Amination reagent as well as preparation method and application thereof". Paragraph 0115-0117; 0148-0149; 0154. . Retrieved 2020/03/12.