1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene

Base Information

• Chemical Name: 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene
• CAS No.: 694499-22-4
• Molecular Formula: C8H5BrF3NO2
• Molecular Weight: 284.032
• Hs Code.: 2904990090
• Mol file: 694499-22-4.mol

Synonyms:2-(bromomethyl)-5-nitrobenzotrifluoride;1-(bromomethyl)-2-(trifluoromethyl)-4-nitrobenzene;QC-3384;1-(Bromomethyl)-4-nitro-2-(trifluoromethyl)-benzene;2-trifluoromethyl-4-nitrobenzyl bromide;4-nitro-2-(trifluoromethyl)benzylbromide;

Chemical Property of 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene

Chemical Property:

• Boiling Point: 276.2±35.0 °C(Predicted)
• PSA: 45.82000
• Density: 1.728±0.06 g/cm3(Predicted)
• LogP: 4.03170
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Nitro-2-(trifluoromethyl)benzyl bromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene

There total 6 articles about 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methyl-4-nitro-2-(trifluoromethyl) benzene (89976-12-5) → 1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene (694499-22-4)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In 1,2-dichloro-ethane; at 80 ℃; for 12h;

Reference yield: 91.0%

1-methyl-4-nitro-2-(trifluoromethyl) benzene (89976-12-5) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene (694499-22-4)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); for 16h; Reflux; Inert atmosphere;

Reference yield: 65.0%

(4-nitro-2-(trifluoromethyl)phenyl)methanol (859027-06-8) → 1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene (694499-22-4)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 25 ℃; for 2h;

upstream raw materials:

1-methyl-4-nitro-2-(trifluoromethyl) benzene

1,2-dichloro-ethane

(2-(trifluoromethyl)phenyl)methanol

2-Trifluoromethylbenzaldehyde

Refernces

• 1、 -. "PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE". Paragraph 0386-0387. . Retrieved 2021/02/18.
• 2、 -. "Alkynyl pyrimidine or alkynyl pyridine compound as well as composition and application thereof". Paragraph 0124-0126. . Retrieved 2020/08/18.