3'-Thymidylic acid, 5'-O-(triphenylmethyl)-, 2-(2-chloro-4-nitrophenyl)ethyl 2-chlorophenyl ester

Base Information

• Chemical Name: 3'-Thymidylic acid, 5'-O-(triphenylmethyl)-, 2-(2-chloro-4-nitrophenyl)ethyl 2-chlorophenyl ester
• CAS No.: 69497-21-8
• Molecular Formula: C₄₃H₃₈Cl₂N₃O₁₀P
• Molecular Weight: 858.669
• Mol file: 69497-21-8.mol

Synonyms:

Chemical Property of 3'-Thymidylic acid, 5'-O-(triphenylmethyl)-, 2-(2-chloro-4-nitrophenyl)ethyl 2-chlorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Thymidylic acid, 5'-O-(triphenylmethyl)-, 2-(2-chloro-4-nitrophenyl)ethyl 2-chlorophenyl ester

There total 6 articles about 3'-Thymidylic acid, 5'-O-(triphenylmethyl)-, 2-(2-chloro-4-nitrophenyl)ethyl 2-chlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-nitrophenyl)ethyl acetate (104-30-3) → (5'-O-Tritylthymidin-3')(2-chlorphenyl)(2-chlor-4-nitrophenylaethyl)phosphorsaeureester (69497-21-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Cl₂, CH₃COONa / trifluoroacetic acid; CCl₄ / 3 h / Ambient temperature

2: HCl / methanol / 1 h / Heating

3: pyridine / 48 h / Ambient temperature

With hydrogenchloride; sodium acetate; chlorine; In pyridine; methanol; tetrachloromethane; trifluoroacetic acid;

DOI:10.1002/hlca.19810640547

Reference yield:

acetic acid phenethyl ester (103-45-7) → (5'-O-Tritylthymidin-3')(2-chlorphenyl)(2-chlor-4-nitrophenylaethyl)phosphorsaeureester (69497-21-8)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄, HNO₃ / acetic anhydride / 1.75 h / -15 °C

2: Cl₂, CH₃COONa / trifluoroacetic acid; CCl₄ / 3 h / Ambient temperature

3: HCl / methanol / 1 h / Heating

4: pyridine / 48 h / Ambient temperature

With hydrogenchloride; sulfuric acid; nitric acid; sodium acetate; chlorine; In pyridine; methanol; tetrachloromethane; acetic anhydride; trifluoroacetic acid;

DOI:10.1002/hlca.19810640547

Reference yield:

Acetic acid 2-(2-chloro-4-nitro-phenyl)-ethyl ester → (5'-O-Tritylthymidin-3')(2-chlorphenyl)(2-chlor-4-nitrophenylaethyl)phosphorsaeureester (69497-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / methanol / 1 h / Heating

2: pyridine / 48 h / Ambient temperature

With hydrogenchloride; In pyridine; methanol;

DOI:10.1002/hlca.19810640547

upstream raw materials:

2-(2-chloro-4-nitro-phenyl)-ethanol

2-(4-nitrophenyl)ethyl acetate

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

acetic acid phenethyl ester

Downstream raw materials:

(2-Chloro-4-nitrophenoxy)ethylene

Phosphoric acid 2-(2-chloro-4-nitro-phenyl)-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Refernces