Isonicotinaldehyde (Z)-oxime

Base Information

• Chemical Name: Isonicotinaldehyde (Z)-oxime
• CAS No.: 696-53-7
• Molecular Formula: C6H6N2O
• Molecular Weight: 122.126
• Mol file: 696-53-7.mol

Synonyms:Isonicotinaldoxime;Isonicotinaldehyde oxime;4-Pyridine aldoxime;Pyridine-4-aldoxime;4-Pyridinecarboxaldehyde,oxime;Pyridine,4-formyl-,oxime;

Chemical Property of Isonicotinaldehyde (Z)-oxime

Chemical Property:

• PSA: 45.22000
• LogP: 0.80020

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isonicotinaldehyde (Z)-oxime

There total 2 articles about Isonicotinaldehyde (Z)-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → pyridin-4-aldoxime (696-53-7) + 4-pyridinealdoxime (1637-52-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In ethanol; water; at 20 ℃; for 3h;

DOI:10.1002/cmdc.201300144

Reference yield:

→ pyridin-4-aldoxime (696-53-7)

Guidance literature:

Picolin-(4), fl. NH3, NaNH2, Butylnitrit, Ae.;

DOI:10.1021/jo01034a048

Reference yield: 86.0%

pyridin-4-aldoxime (696-53-7) → pyridine-4-carbonitrile (100-48-1)

Guidance literature:

pyridin-4-aldoxime; With 2-chloro-1-methyl-pyridinium iodide; In dichloromethane; at 20 ℃; for 0.166667h;

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1081/SCC-120034158

upstream raw materials:

pyridine-4-carbaldehyde

Downstream raw materials:

pyridine-4-carbonitrile

4-ethoxycarbonyl-5-methyl-3-pyridin-4-yl-isoxazole

Refernces

• 1、 Zhu, Junjie,Ye, Yangliang,Ning, Mengmeng,Mandi, Attila,Feng, Ying,Zou, Qingan,Kurtan, Tibor,Leng, Ying,Shen, Jianhua. "Design, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists". supporting information. p. 1210 - 1223. Retrieved 2013/07/26.