Benzenepropanol, methanesulfonate

Base Information

• Chemical Name: Benzenepropanol, methanesulfonate
• CAS No.: 69804-99-5
• Molecular Formula: C10H14O3S
• Molecular Weight: 214.285
• Mol file: 69804-99-5.mol

Synonyms:3-phenylpropyl methyl sulfonate;3-phenylpropan-1-ol mesylate ester;3-phenylpropyl methanesulphonate;3-phenylpropyl methanesulfonate;3-phenylpropyl methansulfonate;Methanesulfonic acid 3-phenylpropyl ester;

Chemical Property of Benzenepropanol, methanesulfonate

Chemical Property:

• PSA: 51.75000
• LogP: 2.67620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanol, methanesulfonate

There total 9 articles about Benzenepropanol, methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Phenyl-1-propanol (122-97-4) + methanesulfonyl chloride (124-63-0) → 3-phenylpropanol methanesulfonate (69804-99-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm0306374

Reference yield: 56.0%

3-phenyl-propionaldehyde (104-53-0) + methanesulfonyl chloride (124-63-0) → 3-phenylpropanol methanesulfonate (69804-99-5)

Guidance literature:

3-phenyl-propionaldehyde; With sodium tetrahydroborate; ethanol; at 20 ℃; for 3h; Inert atmosphere;

methanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02722

Reference yield:

trimethylsilyl methanesulfonate (10090-05-8) + 1-fluoro-3-phenylpropane (2038-62-2) → 3-phenylpropanol methanesulfonate (69804-99-5)

Guidance literature:

With tris(pentafluorophenyl)borate; In 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h; Glovebox; Schlenk technique;

DOI:10.1002/chem.201806272

upstream raw materials:

3-Phenyl-1-propanol

methanesulfonyl chloride

benzyl-methyl-amine

Benzyl-isopropyl-amin

Downstream raw materials:

2-(3-phenylpropoxy)ethanol

2-(methyl(3-phenylpropyl)amino)ethanol

4-phenylbutyronitrile

1-(3-phenylpropyl)-1H-pyrrole

Refernces

• 1、 Lebel, Hélène,Mathieu, Gary,Patel, Heena. "Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides". . p. 2157 - 2168. Retrieved 2020/11/23.
• 2、 Xia, Aiyou,Lv, Peizhuo,Xie, Xin,Liu, Yuanhong. "Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2". supporting information. p. 7842 - 7847. Retrieved 2020/11/02.