2-AMINOPHENYLACETIC ACID

Base Information

• Chemical Name: 2-AMINOPHENYLACETIC ACID
• CAS No.: 69-91-0
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• Mol file: 69-91-0.mol

Synonyms:Glycine,2-phenyl;2-Aminophenylacetic Acid;RARECHEM AL BO 1334;Benzeneacetic acid, α-amino-;O-AMINOPHENYLACETIC ACID;a-Phenylglycine;

Chemical Property of 2-AMINOPHENYLACETIC ACID

Chemical Property:

• Melting Point: 123-127oC(lit.)
• Refractive Index: 1.5635 (rough estimate)
• Boiling Point: 273.17°C (rough estimate)
• PSA: 63.32000
• Density: 1.2023 (rough estimate)
• LogP: 1.47130

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINOPHENYLACETIC ACID

There total 2 articles about 2-AMINOPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-formyl-DL-α-phenylglycine (67421-74-3) → L-α-phenylglycine (69-91-0,875-74-1,2835-06-5,2935-35-5)

Guidance literature:

DOI:10.1246/bcsj.60.661

Reference yield:

α-Hydroxyaminophenylacetic acid (13782-55-3) → D-α-phenylglycine (875-74-1) + L-α-phenylglycine (69-91-0,875-74-1,2835-06-5,2935-35-5)

Guidance literature:

With (-)-DHLA; iron(II); Product distribution; Mechanism; investigation of stereoselective reduction with var. optically active thiols-Fe(II); pH 9.8;

DOI:10.1246/cl.1985.999

Reference yield: 85.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + L-α-phenylglycine (69-91-0,875-74-1,2835-06-5,2935-35-5) → N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine (102410-65-1,111524-95-9,163883-97-4)

Guidance literature:

upstream raw materials:

α-Hydroxyaminophenylacetic acid

N-formyl-DL-α-phenylglycine

Downstream raw materials:

N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine

(R)-2-phenylglycine methyl ester hydrochloride salt

Refernces

• 1、 Nambu, Yoko,Endo, Takeshi. "STEREOSELECTIVE REDUCTION OF RACEMIC N-HYDROXYAMINO ACIDS BY OPTICALLY ACTIVE THIOLS-IRON(II)". . p. 999 - 1002. Retrieved 2007/10/02.