2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-
• CAS No.: 70030-52-3
• Molecular Formula: C15H12OS
• Molecular Weight: 240.326
• Mol file: 70030-52-3.mol

Synonyms:

Chemical Property of 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-

There total 34 articles about 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiophenol (108-98-5) + Cinnamic acid (621-82-9) → S-phenyl thiocinnamate (70030-52-3,21122-38-3)

Guidance literature:

With polyphosphate ester; at 20 ℃;

DOI:10.1016/j.ejmech.2011.09.008

Reference yield: 97.0%

(E)-3-phenylacrylic acid (140-10-3) + thiophenol (108-98-5) → (E)-S-phenyl 3-phenylprop-2-enethioate (70030-52-3)

Guidance literature:

With dmap; picryl fluoride; In acetonitrile; for 12h; Ambient temperature;

DOI:10.1246/cl.1981.133

Reference yield: 93.0%

diphenyldisulfane (882-33-7) + (E)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-phenylprop-2-en-1-one (328012-09-5) → (E)-S-phenyl 3-phenylprop-2-enethioate (70030-52-3)

Guidance literature:

diphenyldisulfane; With samarium diiodide; In tetrahydrofuran; at 20 ℃;

(E)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-phenylprop-2-en-1-one; In tetrahydrofuran; at 20 ℃; for 0.5h;

upstream raw materials:

ethyl 3-phenyl-2-propenoate

phenylthiotrimethylsilane

cinnamoyl chloride

thiophenol

Downstream raw materials:

tert-butyl cinnamate

1-thioflavone

2-phenyl-thiochroman-4-one

diphenyl sulfide

Refernces

• 1、 Ai, Han-Jun,Lu, Wangyang,Wu, Xiao-Feng. "Ligand-Controlled Regiodivergent Thiocarbonylation of Alkynes toward Linear and Branched α,β-Unsaturated Thioesters". supporting information. p. 17178 - 17184. Retrieved 2021/06/28.
• 2、 McGrath, Kevin P.,Hubbell, Aran K.,Zhou, Yuebiao,Santos, Damián Padín,Torker, Sebastian,Romiti, Filippo,Hoveyda, Amir H.. "Catalytic Enantioselective Conjugate Addition of Stereodefined Di- and Trisubstituted Alkenylaluminum Compounds to Acyclic Enones". supporting information. p. 370 - 375. Retrieved 2019/12/24.