3-Furancarboxylic acid, hydrazide

Base Information

• Chemical Name: 3-Furancarboxylic acid, hydrazide
• CAS No.: 70150-84-4
• Molecular Formula: C5H6N2O2
• Molecular Weight: 126.11300
• Mol file: 70150-84-4.mol

Synonyms:furan-3-carbohydrazide;3-furoic hydrazide;3-furancarboxylic acid hydrazide;furan-3-carboxylic acid hydrazide;3-furoylcarbohydrazide;Furan-3-carbonsaeure-hydrazid;

Chemical Property of 3-Furancarboxylic acid, hydrazide

Chemical Property:

• PSA: 68.26000
• LogP: 0.97430

Purity/Quality:

99% ^*data from raw suppliers

furan-3-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Furancarboxylic acid, hydrazide

There total 5 articles about 3-Furancarboxylic acid, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,2,2-trichloro-1-(furan-3-yl)ethan-1-one (743420-66-8) → 3-furoylcarbohydrazide (70150-84-4)

Guidance literature:

With hydrazine hydrate; In toluene; at 100 ℃; for 20h;

DOI:10.1016/j.tetlet.2004.05.109

Reference yield: 52.9%

3-Furoic acid (488-93-7) → 3-furoylcarbohydrazide (70150-84-4)

Guidance literature:

3-Furoic acid; With sulfuric acid; In methanol; at 60 ℃; for 3h;

With hydrazine hydrate; In ethanol; at 100 ℃; for 5h;

Reference yield: 50.0%

methyl furan-3-carboxylate (13129-23-2) → 3-furoylcarbohydrazide (70150-84-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 18h; Reflux;

DOI:10.1002/cmdc.201900716

upstream raw materials:

ethyl 3-furancarboxylate

2,2,2-trichloro-1-(furan-3-yl)ethan-1-one

3-trichloroacetyl-4,5-dihydrofuran

methyl furan-3-carboxylate

Downstream raw materials:

(5-Furan-3-yl-[1,3,4]oxadiazol-2-ylmethyl)-carbamic acid benzyl ester

C₁₉H₂₂N₄O₂S

C₁₆H₁₂N₂O₄

2-(furan-3-yl)-5-phenyl-1,3,4-oxadiazole

Refernces

• 1、 Alves, Marina A.,Chaves, Lorrane S.,Fernandes, Patrícia D.,Fraga, Carlos A. M.,Guerra, Fabiana S.,Rodrigues, Daniel A.,Sagrillo, Fernanda S.,Sant'Anna, Carlos M. R.,Thota, Sreekanth,de Sena M. Pinheiro, Pedro. "Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors". supporting information. . Retrieved 2020/02/25.
• 2、 Romaine, Ian M.,Taylor, Robert W.,Saidu, Samsudeen P.,Kim, Kwangho,Sulikowski, Gary A.,Zwiebel, Laurence J.,Waterson, Alex G.. "Narrow SAR in odorant sensing Orco receptor agonists". . p. 2613 - 2616. Retrieved 2014/06/09.