(S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid

Base Information Edit

Chemical Name:(S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid
CAS No.:70396-18-8
Molecular Formula:C13H24N2O5
Molecular Weight:288.344
Hs Code.:
DSSTox Substance ID:DTXSID90562682
Nikkaji Number:J1.109.222E
Wikidata:Q82446935
Mol file:70396-18-8.mol

Synonyms:70396-18-8;(tert-Butoxycarbonyl)-L-valyl-L-alanine;Boc-Val-Ala-OH;(S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid;(2S)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]propanoic acid;(S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid;MFCD22381612;SCHEMBL7285160;DTXSID90562682;FHBCSPANXVQYCP-IUCAKERBSA-N;tert-butoxycarbonyl-valinyl-alanine;AKOS026673776;HY-W038703;BP-27958;CS-16371;N-(tert-Butoxycarbonyl)-L-valyl-L-alanine;CS-0096161;D75728;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanine

Suppliers and Price of (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Boc-Val-Ala-OH 95+%
1g
$ 923.00

Ambeed
Boc-Val-Ala-OH 95%
1g
$ 54.00

Ambeed
Boc-Val-Ala-OH 95%
250mg
$ 28.00

Ambeed
Boc-Val-Ala-OH 95%
5g
$ 198.00

AK Scientific
(S)-2-((S)-2-(Tert-butoxycarbonylamino)-3-methylbutanamido)propanoicacid
1g
$ 132.00

Acrotein
N-Boc-L-valyl-L-alanine 97%
25g
$ 660.00

Acrotein
N-Boc-L-valyl-L-alanine 97%
5g
$ 220.00

Acrotein
N-Boc-L-valyl-L-alanine 97%
1g
$ 73.33

Total 6 raw suppliers

Chemical Property of (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid Edit

Chemical Property:

Boiling Point:493.3±30.0 °C(Predicted)
PKA:3.50±0.10(Predicted)
PSA：111.71000
Density:1.121±0.06 g/cm3(Predicted)
LogP:2.16970
Storage Temp.:2-8°C
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:288.16852187
Heavy Atom Count:20
Complexity:373

Purity/Quality:

98% ^*data from raw suppliers

Boc-Val-Ala-OH 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)NC(C)C(=O)O)NC(=O)OC(C)(C)C
Isomeric SMILES:C[C@@H](C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C
Description Boc-Val-Ala-OH is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid

There total 9 articles about (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-methylbutanamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 130380-44-8
N-tert-Butyloxycarbonyl-L-valyl-L-alanin-heptylester

: 70396-18-8
(2S)-2-((2S)-2-[(tert-butoxy)carbonyl]amino-3-methylbutyrylamino)propionic acid

Guidance literature:: With sodium hydroxide; Na-phosphate buffer; phenylmethylsulphonyl fluoride; In acetone; for 37h; pH 7.0; Rhizopus niveus lipase;