Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester
• CAS No.: 70415-72-4
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Mol file: 70415-72-4.mol

Synonyms:

Chemical Property of Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester

There total 5 articles about Benzoic acid, 4-methoxy-, 2-pyridinylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

para-iodoanisole (696-62-8) + 2-pyridylmethyl formate (401515-97-7) → 4-methoxybenzoic acid 2-pyridinylmethyl ester (70415-72-4)

Guidance literature:

With sodium hydrogencarbonate; dodecacarbonyl-triangulo-triruthenium; palladium dichloride; In N,N-dimethyl-formamide; at 135 ℃; for 6h;

DOI:10.1021/jo026591o

Reference yield: 80.0%

2-Hydroxymethylpyridine (586-98-1) + carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) → 4-methoxybenzoic acid 2-pyridinylmethyl ester (70415-72-4)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,10-Phenanthroline; potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 22h; Glovebox;

DOI:10.1039/d2cc00876a

Reference yield: 72.0%

α-picoline (109-06-8) + 4-methoxybenzoic acid (100-09-4) → 4-methoxybenzoic acid 2-pyridinylmethyl ester (70415-72-4)

Guidance literature:

With oxygen; copper(I) bromide; In chlorobenzene; at 130 ℃; for 30h; under 760.051 Torr; Schlenk technique; Sealed tube; Green chemistry;

DOI:10.1021/acs.joc.8b02794

upstream raw materials:

para-iodoanisole

2-pyridylmethyl formate

2-Hydroxymethylpyridine

α-picoline

Downstream raw materials:

2-Hydroxymethylpyridine

methoxybenzene

Refernces

• 1、 Cheng, Li,Sun, Yuqian,Wang, Wenrong,Yao, Changsheng,Li, Tuan-Jie. "Ligand-Free Copper(I)-Catalyzed Benzylic Acyloxylation of 2-Alkylpyridines under Aerobic Conditions". . p. 3074 - 3082. Retrieved 2019/03/11.
• 2、 Ko, Sangwon,Lee, Chongmok,Choi, Moon-Gun,Na, Youngim,Chang, Sukbok. "Chelation-accelerated sequential decarbonylation of formate and alkoxycarbonylation of aryl halides using a combined Ru and Pd catalyst". . p. 1607 - 1610. Retrieved 2007/10/03.