6-BROMO-3-FORMYLCHROMONE

Base Information

• Chemical Name: 6-BROMO-3-FORMYLCHROMONE
• CAS No.: 52817-12-6
• Molecular Formula: C10H5BrO3
• Molecular Weight: 253.052
• Hs Code.: 2914700090
• Mol file: 52817-12-6.mol

Synonyms:6-Bromo-3-formylchromone;6-Bromo-4-oxo-4H-1-benzopyran-3-carboxaldehyde;6-Bromochromone-3-carboxaldehyde;

Chemical Property of 6-BROMO-3-FORMYLCHROMONE

Chemical Property:

• Melting Point: 190-193 °C(lit.)
• Refractive Index: 1.713
• Boiling Point: 365.7 °C at 760 mmHg
• Flash Point: 175 °C
• PSA: 47.28000
• Density: 1.835g/cm³
• LogP: 2.36800
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-3-Formylchromone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 6-Bromo-3-formylchromone is the suitable reagent used in a study to investigate the multidrug resistance reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. It may be used in the preparation of chromone containing sulfonamides.

Technology Process of 6-BROMO-3-FORMYLCHROMONE

There total 9 articles about 6-BROMO-3-FORMYLCHROMONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

acetic acid acetoxy-(6-bromo-4-oxo-4H-chromen-3-yl)-methyl ester → 6-bromo-4-oxo-4H-chromene-3-carbaldehyde (52817-12-6)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; at 70 ℃; for 2h;

Reference yield: 86.0%

5-Bromo-2-hydroxyacetophenone (1450-75-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-bromo-4-oxo-4H-chromene-3-carbaldehyde (52817-12-6)

Guidance literature:

N,N-dimethyl-formamide; With bis(trichloromethyl) carbonate; In 1,2-dichloro-ethane; at 0 - 20 ℃;

5-Bromo-2-hydroxyacetophenone; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 4.5h; Further stages.;

DOI:10.1080/00304940709458601

Reference yield:

5-Bromo-2-hydroxyacetophenone (1450-75-5) → 6-bromo-4-oxo-4H-chromene-3-carbaldehyde (52817-12-6)

Guidance literature:

With trichlorophosphate; In water; N,N-dimethyl-formamide;

upstream raw materials:

5-Bromo-2-hydroxyacetophenone

N,N-dimethyl-formamide

4-bromo-phenol

4-bromophenyl acetate

Downstream raw materials:

6-bromo-3-(4,5-diphenyl-1H-imidazol-2-yl)-chromen-4-one

6-bromochromone-3-carbonitrile

C₂₀H₁₂BrN₃O₃

ethyl 5-(5-bromo-2-hydroxybenzoyl)-3-chloro-2-hydroxybenzoate

Refernces

• 1、 -. "Chromone dioxadiazole compound as well as preparation method and application thereof". Paragraph 0021-0023. . Retrieved 2021/10/30.
• 2、 Huang, Ming,Jiang, Neng,Kong, Ling-Yi,Lan, Jin-Shuai,Wang, Xiao-Bing,Yin, Fu-Cheng. "Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease". . p. 225 - 233. Retrieved 2020/04/22.