L-2-Hydroxyphenylalanine

Base Information

• Chemical Name: L-2-Hydroxyphenylalanine
• CAS No.: 709-16-0
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 709-16-0.mol

Synonyms:2-amino-3-(2-hydroxyphenyl)propanoic acid;2-tyrosine;

Chemical Property of L-2-Hydroxyphenylalanine

Chemical Property:

• PSA: 83.55000
• LogP: 1.04690

Purity/Quality:

99%, ^*data from raw suppliers

L-2-Hydroxyphenylalanine 98 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-2-Hydroxyphenylalanine

There total 24 articles about L-2-Hydroxyphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-[(2-hydroxy-benzylidene)amino]chromen-2-one (1473-60-5,910217-51-5) → 2-hydroxy-phenylalanine (709-16-0,2370-61-8,7423-92-9,24008-77-3)

Guidance literature:

With hydrogen; palladium; In acetic acid; for 48h;

DOI:10.1002/jhet.5570230118

Reference yield: 65.0%

3-salicylaminocoumarin (97472-95-2) → 2-hydroxy-phenylalanine (709-16-0,2370-61-8,7423-92-9,24008-77-3)

Guidance literature:

With hydrogen; palladium; In acetic acid; for 48h;

DOI:10.1002/jhet.5570230118

Reference yield: 60.0%

aminocoumarine (1635-31-0) → 2-hydroxy-phenylalanine (709-16-0,2370-61-8,7423-92-9,24008-77-3)

Guidance literature:

With hydrogen; palladium; In acetic acid; for 48h;

DOI:10.1002/jhet.5570230118

upstream raw materials:

Hippuric Acid

3-acetamidocoumarin

N-benzoyl-2-hydroxy-phenylalanine

3,6-bis-(2-acetoxy-benzylidene)-piperazine-2,5-dione

Downstream raw materials:

N-glycyl-2-hydroxy-phenylalanine

C₁₇H₂₀N₂O₅

2-hydroxy-5-nitro-phenylalanine

N-(tert-butoxycarbonyl)-β-(3,5-dinitro-2-methoxyphenyl)-α-alanine

Refernces

• 1、 Danthi, Satyavijayan Narasimhan,Hill, Ronald A.. "Synthesis of chirally pure 2,5-disubstituted diketopiperazines derived from trisubstituted phenylalanines". . p. 835 - 844. Retrieved 2007/10/03.
• 2、 Ishimitsu, Susumu,Fujimoto, Sadaki,Ohara, Akira. "Studies on the Hydroxylation of Phenylalanine by 6,7-Dimethyl-5,6,7,8-tetrahydropteridine". . p. 752 - 756. Retrieved 2007/10/02.