N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Base Information

• Chemical Name: N-(4-phenyl-1,3-thiazol-2-yl)acetamide
• CAS No.: 5039-09-8
• Molecular Formula: C11H10 N2 O S
• Molecular Weight: 218.279
• Mol file: 5039-09-8.mol

Synonyms:Thiazole,2-acetamido-4-phenyl- (6CI,7CI); 2-Acetamido-4-phenylthiazole;N-(4-Phenylthiazol-2-yl)acetamide; NSC 18793; NSC 45985

Chemical Property of N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Chemical Property:

• Density: 1.28g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-phenyl-1,3-thiazol-2-yl)acetamide

There total 10 articles about N-(4-phenyl-1,3-thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3‐oxo‐N‐(4‐phenylthiazol‐2yl)butanamide (87273-75-4) → 2-acetamide-4-phenyl-1,3-thiazole (5039-09-8)

Guidance literature:

With ammonium acetate; In acetic acid; for 4h; Heating;

Reference yield: 94.0%

2-Amino-4-phenylthiazole (2010-06-2) + acetyl chloride (75-36-5) → 2-acetamide-4-phenyl-1,3-thiazole (5039-09-8)

Guidance literature:

With carbon-silica composite from starch (7.5 molpercent SO₃H); at 60 ℃; for 0.75h; solvent-free conditions;

DOI:10.1039/c0gc00900h

Reference yield: 92.0%

2-Amino-4-phenylthiazole (2010-06-2) + acetic anhydride (108-24-7) → 2-acetamide-4-phenyl-1,3-thiazole (5039-09-8)

Guidance literature:

With sulfuric acid; sodium acetate; for 2h; Heating;

upstream raw materials:

2-Amino-4-phenylthiazole

acetic anhydride

acetyl chloride

3‐oxo‐N‐(4‐phenylthiazol‐2yl)butanamide

Downstream raw materials:

N-(4-phenyl-5-thiocyanato-thiazol-2-yl)-acetamide

N-(5-diethylaminomethyl-4-phenyl-thiazol-2-yl)-acetamide

4-(2-acetylamino-thiazol-4-yl)-benzenesulfonyl chloride

N-(4-phenyl-5-piperidin-1-ylmethyl-thiazol-2-yl)-acetamide

Refernces

• 1、 Tang, Xiaodong,Yang, Jidan,Zhu, Zhongzhi,Zheng, Meifang,Wu, Wanqing,Jiang, Huanfeng. "Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions". . p. 11461 - 11466. Retrieved 2016/11/28.
• 2、 Gupta, Princy,Paul, Satya. "Amorphous carbon-silica composites bearing sulfonic acid as solid acid catalysts for the chemoselective protection of aldehydes as 1,1-diacetates and for N-, O- and S-acylations". experimental part. p. 2365 - 2372. Retrieved 2011/10/31.