2-Oxazolamine, N-(2-chloroethyl)-4,5-dihydro-

Base Information

• Chemical Name: 2-Oxazolamine, N-(2-chloroethyl)-4,5-dihydro-
• CAS No.: 71353-16-7
• Molecular Formula: C5H9ClN2O
• Molecular Weight: 148.592
• Mol file: 71353-16-7.mol

Synonyms:

Chemical Property of 2-Oxazolamine, N-(2-chloroethyl)-4,5-dihydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxazolamine, N-(2-chloroethyl)-4,5-dihydro-

There total 1 articles about 2-Oxazolamine, N-(2-chloroethyl)-4,5-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-bis(2-chloroethyl)-1-nitrosourea (154-93-8) → 1,3-bis(2-chloroethyl)urea (2214-72-4) + 2-<(2-chloroethyl)amino>-2-oxazoline (71353-16-7) + 1-(2-chloroethyl)imidazolidin-2-one (2387-20-4) + ethanol (64-17-5) + ethylamine (75-04-7,85404-22-4)

Guidance literature:

With potassium hydroxide; aluminum nickel; In methanol; Product distribution; Mechanism; degradation under various conditions (HBr in glac. CH₃CO₂H) with preparation of nonmutagenic reaction mixtures of products;

DOI:10.1002/jps.2600780811

Reference yield: 45.0%

2-<(2-chloroethyl)amino>-2-oxazoline (71353-16-7) → 2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine (76310-08-2)

Guidance literature:

With n-Butyl nitrite; sodium methylate; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1021/jm00135a007

Reference yield:

2-<(2-chloroethyl)amino>-2-oxazoline (71353-16-7) → 2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride (73771-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / n-butyl nitrite, sodium methoxide / diethyl ether / 12 h / Ambient temperature

2: HCl(g) / diethyl ether / 0.5 h / 0 - 4 °C

With hydrogenchloride; n-Butyl nitrite; sodium methylate; In diethyl ether;

DOI:10.1021/jm00135a007

upstream raw materials:

1,3-bis(2-chloroethyl)-1-nitrosourea

Downstream raw materials:

2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine

2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride

Refernces