1-Chloro-7-methylnaphthalene

Base Information

• Chemical Name: 1-Chloro-7-methylnaphthalene
• CAS No.: 71778-30-8
• Molecular Formula: C11H9Cl
• Molecular Weight: 176.645
• Mol file: 71778-30-8.mol

Synonyms:1-chloro-7-methyl-naphthalene;1-Chlor-7-methyl-naphthalin;7-Methyl-1-chlor-naphthalin;

Chemical Property of 1-Chloro-7-methylnaphthalene

Chemical Property:

• PSA: 0.00000
• LogP: 3.80160

Purity/Quality:

97% ^*data from raw suppliers

1-Chloro-7-methylnaphthalene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloro-7-methylnaphthalene

There total 9 articles about 1-Chloro-7-methylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-allyltoluene (3333-13-9) → 1-chloro-7-methylnaphthalene (71778-30-8)

Guidance literature:

With Bromotrichloromethane; iron; In ethanol; at 20 ℃; for 2h; Irradiation;

DOI:10.1002/adsc.202001249

Reference yield:

2-(2-chlorophenyl)acetyl chloride (51512-09-5) → 1-chloro-7-methylnaphthalene (71778-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / CH₂Cl₂ / 0.25 h / -10 °C

2: TiCl₄ / CH₂Cl₂; tetrahydrofuran / 2 h / 0 °C

3: Ph₃COH, TFA / 48 h / Ambient temperature

With aluminium trichloride; triphenylmethyl alcohol; titanium tetrachloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00069a006

Reference yield:

1,2-diethynyl-4-methylbenzene (412041-50-0) → 1-chloro-7-methylnaphthalene (71778-30-8) + 1-chloro-6-methylnaphthalene (109962-22-3)

Guidance literature:

With hydrogenchloride; platinum(II) chloride; In water; at 100 ℃; for 11h; Title compound not separated from byproducts;

DOI:10.1021/jo0518295

upstream raw materials:

1-methyl-4-(2,4,4,4-tetrachloro-butyl)-benzene

8-chloro-2-methyl-1,2,3,4-tetrahydronaphthalen-2-ol

1,2-diethynyl-4-methylbenzene

8-chloro-3,4-dihydro-2(1H)-naphthalenone

Downstream raw materials:

4,4,5,5-tetramethyl-2-(7-methylnaphthalen-1-yl)-1,3,2-dioxaborolane

8-chloronaphthalene-2-carboxaldehyde

Refernces

• 1、 -. "DIHYDROIMIDAZOTHIAZOLE DERIVATIVES". Page/Page column 37. . Retrieved 2008/06/13.
• 2、 Cordi,Berque-Bestel,Persigand,Lacoste,Newman-Tancredi,Audinot,Millan. "Potential antidepressants displayed combined α2-adrenoceptor antagonist and monoamine uptake inhibitor properties". . p. 787 - 805. Retrieved 2007/10/03.