1-BENZYL-2-CHLOROMETHYL-1H-BENZOIMIDAZOLE

Base Information

• Chemical Name: 1-BENZYL-2-CHLOROMETHYL-1H-BENZOIMIDAZOLE
• CAS No.: 7192-00-9
• Molecular Formula: C15H13ClN2
• Molecular Weight: 256.735
• Hs Code.: 2933990090
• Mol file: 7192-00-9.mol

Synonyms:1-Benzyl-2-chloromethyl-1H-benzoimidazole;1-benzyl-2-chloromethylbenzimidazole;1-Benzyl-2-chlormethyl-1H-benzimidazol;2-(chloromethyl)-1-benzylbenzimidazole;1-Benzyl-2-(chloromethyl)-1H-benzo[d]imidazole;1-Benzyl-2-(chloromethyl)-1H-benzimidazole;

Chemical Property of 1-BENZYL-2-CHLOROMETHYL-1H-BENZOIMIDAZOLE

Chemical Property:

• PSA: 17.82000
• LogP: 3.82340

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl-2-chloromethyl-1H-benzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-2-CHLOROMETHYL-1H-BENZOIMIDAZOLE

There total 9 articles about 1-BENZYL-2-CHLOROMETHYL-1H-BENZOIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloromethyl-1H-benzimidazole (4857-04-9) + benzyl chloride (100-44-7) → 1-benzyl-2-(chloromethyl)-1H-benzo[d]imidazole (7192-00-9)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; at 20 ℃; for 0.133333h;

DOI:10.1002/jhet.450

Reference yield: 71.4%

N-benzyl-1,2-phenylenediamine (5822-13-9) + chloroacetic acid (79-11-8) → 1-benzyl-2-(chloromethyl)-1H-benzo[d]imidazole (7192-00-9)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1007/s00044-020-02605-5

Reference yield:

(1-benzyl-1H-benzo[d]imidazol-2-yl)methanol (6646-70-4) → 1-benzyl-2-(chloromethyl)-1H-benzo[d]imidazole (7192-00-9)

Guidance literature:

With thionyl chloride; In chloroform; at 20 ℃; for 18h;

upstream raw materials:

N-benzyl-1,2-phenylenediamine

chloroacetic acid

2-chloromethyl-1H-benzimidazole

benzyl chloride

Downstream raw materials:

1-benzyl-2-(piperazin-1-ylmethyl)-1H-benzo[d]imidazole

1-benzyl-2-((4-(phenylsulfonyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole

(4-((1-benzyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(phenyl)methanone

4-((1-benzyl-1H-benzo[d]imidazol-2-yl)methyl)-N-phenylpiperazine-1-carboxamide

Refernces

• 1、 Gong, Yanmei,Ma, Haiyan. "High performance benzoimidazolyl-based aminophenolate zinc complexes for isoselective polymerization of: Rac -lactide". . p. 10112 - 10115. Retrieved 2019/08/30.
• 2、 Wang, Ya-Nan,Bheemanaboina, Rammohan R. Yadav,Gao, Wei-Wei,Kang, Jie,Cai, Gui-Xin,Zhou, Cheng-He. "Discovery of Benzimidazole–Quinolone Hybrids as New Cleaving Agents toward Drug-Resistant Pseudomonas aeruginosa DNA". . p. 1004 - 1017. Retrieved 2018/04/30.