ISONICOTINIC ACID 2-(PYRIDINE-4-CARBONYLOXY)-ETHYL ESTER

Base Information

• Chemical Name: ISONICOTINIC ACID 2-(PYRIDINE-4-CARBONYLOXY)-ETHYL ESTER
• CAS No.: 72121-34-7
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.25600
• Mol file: 72121-34-7.mol

Synonyms:ethylene glycol diisonicotinate;ethane diyl di-4-pyridine carboxylate;ethane-1,2-diyl bis(isonicotinate);O,O'-bisnicotinoyl-1,4-butylenediol;1,2-ethanediyl di-4-pyridinecarboxylate;ethanediyl bis(isonicotinate);

Chemical Property of ISONICOTINIC ACID 2-(PYRIDINE-4-CARBONYLOXY)-ETHYL ESTER

Chemical Property:

• PSA: 78.38000
• LogP: 1.49040

Purity/Quality:

99% ^*data from raw suppliers

Isonicotinicacid2-(pyridine-4-carbonyloxy)-ethylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ISONICOTINIC ACID 2-(PYRIDINE-4-CARBONYLOXY)-ETHYL ESTER

There total 4 articles about ISONICOTINIC ACID 2-(PYRIDINE-4-CARBONYLOXY)-ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

isonicotinoyl chloride hydrochloride (39178-35-3) + ethylene glycol (107-21-1) → 1,2-ethanediyl di-4-pyridine carboxylate (72121-34-7)

Guidance literature:

With pyridine; at 100 ℃; for 3h;

DOI:10.1002/ejoc.201001668

Reference yield: 79.0%

sodium pyridine-4-carboxylate (16887-79-9) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1,2-ethanediyl di-4-pyridine carboxylate (72121-34-7)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1134/S1070363214040252

Reference yield:

4-(chlorocarbonyl)pyridine (14254-57-0) + ethylene glycol (107-21-1) → 1,2-ethanediyl di-4-pyridine carboxylate (72121-34-7)

Guidance literature:

Heating;

DOI:10.1080/15533174.2011.591336

upstream raw materials:

isonicotinoyl chloride hydrochloride

ethylene glycol

4-(chlorocarbonyl)pyridine

sodium pyridine-4-carboxylate

Refernces

• 1、 Busi, Marco,Cantadori, Barbara,Boccini, Francesca,De Zorzi, Rita,Geremia, Silvano,Dalcanale, Enrico. "Molecular recognition with ditopic cavitand re complexes". . p. 2629 - 2642. Retrieved 2011.
• 2、 Grosshans, Philippe,Jouaiti, Abdelaziz,Bulach, Veronique,Planeix, Jean-Marc,Hosseini, Mir Wais,Kyritsakas, Nathalie. "Design and structural analysis of metallamacrocycles based on a combination of ethylene glycol bearing pyridine units with zinc, cobalt and mercury". . p. 453 - 458. Retrieved 2004.
• 3、 Eichhorn, Thomas,Hey-Hawkins, Evamarie,Maksimovi-Ivani, Danijela,Moji, Marija,Schmidt, Jürgen,Mijatovi, Sanja,Schmidt, Harry,Kaluderovi, Goran N.. "Binuclear dichlorido(η6-p-cymene)ruthenium(II) complexes with bis(nicotinate)- And bis (isonicotinate)-polyethylene glycol ester ligands". . p. 20 - 25. Retrieved 2015/01/30.