6-Hydrazino[1,2,4]triazolo[4,3-b]pyridazine

Base Information

• Chemical Name: 6-Hydrazino[1,2,4]triazolo[4,3-b]pyridazine
• CAS No.: 7229-00-7
• Molecular Formula: C5H6N6
• Molecular Weight: 150.14100
• Hs Code.: 2933990090
• European Community (EC) Number: 845-599-7
• ChEMBL ID: CHEMBL1531088
• DSSTox Substance ID: DTXSID90401380
• Nikkaji Number: J1.245.587I
• Wikidata: Q82204467
• Mol file: 7229-00-7.mol

Synonyms:7229-00-7;6-Hydrazino[1,2,4]triazolo[4,3-b]pyridazine;[1,2,4]triazolo[4,3-b]pyridazin-6-ylhydrazine;{[1,2,4]triazolo[4,3-b]pyridazin-6-yl}hydrazine;ChemDiv3_014741;6-Hydrazinyl-[1,2,4]triazolo[4,3-b]pyridazine;MLS001029913;SCHEMBL1302335;CHEMBL1531088;DTXSID90401380;HMS1514O01;HMS2782I22;AKOS000271312;AKOS008031019;IDI1_030539;SMR000426862;VS-01529;CS-0258962;FT-0684021;EN300-71910;[1,2,4]Triazolo[4,3-b]pyridazin-6-yl-hydrazine

Chemical Property of 6-Hydrazino[1,2,4]triazolo[4,3-b]pyridazine

Chemical Property:

• PSA: 81.13000
• LogP: 0.18320
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 150.06539422
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98%min ^*data from raw suppliers

6-hydrazino[1,2,4]triazolo[4,3-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NN=CN2N=C1NN

Technology Process of 6-Hydrazino[1,2,4]triazolo[4,3-b]pyridazine

There total 5 articles about 6-Hydrazino[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-chloro[1,2,4]triazolo[4,3-b]pyridazine (28593-24-0) → 6-hydrazino[1,2,4]triazolo[4,3-b]pyridazine (7229-00-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h;

Reference yield: 20.0%

1-(1-ethoxycarbonylethylene)-2-(1,2,4-triazolo<4,3-b>pyridazinyl-6)-hydrazine (107263-05-8) → 6-amino-1,2,4-triazolo<4,3-b>pyridazine (19195-46-1) + 6-hydrazino[1,2,4]triazolo[4,3-b]pyridazine (7229-00-7) + ethyl-<3-(6H-6-oxo-1,2,4-triazino<4,3-b>1,2,4-triazolo<3,4-f>pyridazinyl-7)-2-methylacrylate> (107263-08-1)

Guidance literature:

With PPA; at 100 ℃; for 5h;

DOI:10.1007/BF00810078

Reference yield:

6-chloro-3-methylenehydrazinopyridazine (158607-16-0) → 6-hydrazino[1,2,4]triazolo[4,3-b]pyridazine (7229-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 15 percent / AcOH, AcONa, Br₂ / 3 h / Heating

2: 89 percent / NH₂NH₂*H₂O / ethanol / 8 h

With bromine; sodium acetate; hydrazine hydrate; acetic acid; In ethanol;

upstream raw materials:

6-chloro[1,2,4]triazolo[4,3-b]pyridazine

1-(1-ethoxycarbonylethylene)-2-(1,2,4-triazolo<4,3-b>pyridazinyl-6)-hydrazine

6-chloro-3-methylenehydrazinopyridazine

3-(2,3-dibromomethylenehydrazino)-6-chloropyridazine

Downstream raw materials:

6-amino-1,2,4-triazolo<4,3-b>pyridazine

6-bromo-s-triazolo<4,3-b>pyridazine

Refernces

• 1、 Baloniak, S.,Katrusiak, A.. "Synthesis and Reactivity of some 1,2,4-Triazolopyridazine Derivatives". . p. 683 - 692. Retrieved 2007/10/02.