Pyrazinemethanamine, a-phenyl-

Base Information

• Chemical Name: Pyrazinemethanamine, a-phenyl-
• CAS No.: 724438-48-6
• Molecular Formula: C11H11N3
• Molecular Weight: 185.228
• Mol file: 724438-48-6.mol

Synonyms:

Chemical Property of Pyrazinemethanamine, a-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrazinemethanamine, a-phenyl-

There total 1 articles about Pyrazinemethanamine, a-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-pyrazine carbonitrile (19847-12-2) + phenylmagnesium chloride (100-59-4) → phenyl(pyrazin-2-yl)methylamine (724438-48-6)

Guidance literature:

2-pyrazine carbonitrile; phenylmagnesium chloride; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejic.200800154

Reference yield: 75.0%

phenyl(pyrazin-2-yl)methylamine (724438-48-6) + benzaldehyde (100-52-7) → N-benzyl-N-[phenyl(pyrazin-2-yl)methyl]amine (1161432-56-9)

Guidance literature:

phenyl(pyrazin-2-yl)methylamine; benzaldehyde; With magnesium sulfate; In methanol; at 20 ℃; for 12h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

DOI:10.1002/ejic.200800154

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + phenyl(pyrazin-2-yl)methylamine (724438-48-6) → 1-phenylimidazo[1,5-a]pyrazine-3(2H)-thione (1039745-73-7)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; Heating / reflux;

upstream raw materials:

2-pyrazine carbonitrile

phenylmagnesium chloride

Downstream raw materials:

1-phenylimidazo[1,5-a]pyrazine-3(2H)-thione

N-benzyl-N-[phenyl(pyrazin-2-yl)methyl]amine

C₁₉H₁₉N₃

Refernces

• 1、 Terrasson, Vincent,Prim, Damien,Marrot, Jerome. "N-heterocyclic benzhydrylamines as new N,N-bidentate ligands in palladium complexes: Synthesis, characterization and catalytic activity". experimental part. p. 2739 - 2745. Retrieved 2009/03/12.