Technology Process of Benzonitrile, 4-[(2S)-3,3-diphenyloxiranyl]-
There total 1 articles about Benzonitrile, 4-[(2S)-3,3-diphenyloxiranyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hypochlorite; 4-Phenylpyridine 1-oxide;
(-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III);
In
dichloromethane;
at 25 ℃;
for 3h;
pH=11.3;
DOI:10.1002/adsc.200303125
- Guidance literature:
-
(S)-4-(3,3-diphenyloxiranyl)-benzonitrile;
With
diisobutylaluminium hydride;
In
hexane;
at -78 ℃;
for 2.25h;
With
ammonium chloride;
In
hexane; ethyl acetate;
at 25 ℃;
for 2h;
Further stages.;
DOI:10.1002/adsc.200303125
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diisopropoxytitanium diazide / benzene / 5.33 h / Heating
2: 4.40 g / H2 / Pd/C / methanol / 15 h / 20 °C / 760 Torr
3: 65 percent / K2CO3 / ethanol / 12 h / Heating
4: 92 percent / DIBALH / hexane; diethyl ether / 1 h / -78 °C
5: 65 percent / NaBH4 / ethanol / 0.5 h / 20 °C
6: 83 percent / acetonitrile / 24 h / 20 °C
With
sodium tetrahydroborate; diisopropoxytitanium diazide; hydrogen; diisobutylaluminium hydride; potassium carbonate;
palladium on activated charcoal;
In
methanol; diethyl ether; ethanol; hexane; acetonitrile; benzene;
DOI:10.1016/j.tet.2005.07.112