3-Chloro-5-methyl-2-phenylpyrazine

Base Information

• Chemical Name: 3-Chloro-5-methyl-2-phenylpyrazine
• CAS No.: 72875-88-8
• Molecular Formula: C11H9ClN2
• Molecular Weight: 204.659
• DSSTox Substance ID: DTXSID90502760
• Wikidata: Q82356052
• Mol file: 72875-88-8.mol

Synonyms:3-Chloro-5-methyl-2-phenylpyrazine;72875-88-8;SCHEMBL11222089;DTXSID90502760

Chemical Property of 3-Chloro-5-methyl-2-phenylpyrazine

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 204.0454260
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=N1)Cl)C2=CC=CC=C2

Technology Process of 3-Chloro-5-methyl-2-phenylpyrazine

There total 1 articles about 3-Chloro-5-methyl-2-phenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-chloro-5-methyl-2-phenyl-pyrazine (72875-88-8)

Guidance literature:

2-Methyl-5-phenyl-pyrazin-1-oxid, POCl3;

Reference yield: 94.0%

3-chloro-5-methyl-2-phenyl-pyrazine (72875-88-8) → 2-methyl-5-phenylpyrazine (58861-90-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 33.0%

3-chloro-5-methyl-2-phenyl-pyrazine (72875-88-8) → 2-azido-6-methyl-3-phenylpyrazine

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 120 ℃; for 12h;

Downstream raw materials:

2-methyl-5-phenylpyrazine