Benzoic acid, 4-methoxy-, 4-fluorophenyl ester

Base Information

• Chemical Name: Benzoic acid, 4-methoxy-, 4-fluorophenyl ester
• CAS No.: 729-39-5
• Molecular Formula: C14H11FO3
• Molecular Weight: 246.238
• Mol file: 729-39-5.mol

Synonyms:

Chemical Property of Benzoic acid, 4-methoxy-, 4-fluorophenyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-methoxy-, 4-fluorophenyl ester

There total 6 articles about Benzoic acid, 4-methoxy-, 4-fluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(4-Methoxybenzoyl)pyrrolidine-2,5-dione (6343-26-6) + 4-fluoroboronic acid (1765-93-1) → 4-methoxybenzoic acid 4-fluorophenyl ester (729-39-5)

Guidance literature:

With tert.-butylhydroperoxide; dmap; In water; toluene; at 100 ℃; for 12h; Schlenk technique;

DOI:10.1002/ejoc.202100478

Reference yield: 82.0%

4-fluoroboronic acid (1765-93-1) + 4-methoxy-benzaldehyde (123-11-5) → 4-methoxybenzoic acid 4-fluorophenyl ester (729-39-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(mesityl)imidazolium chloride; In dimethyl sulfoxide; at 80 ℃; for 0.5h;

DOI:10.1002/asia.201200076

Reference yield: 81.0%

4-Fluorophenol (371-41-5) + 4-methoxy-benzoyl chloride (100-07-2) → 4-methoxybenzoic acid 4-fluorophenyl ester (729-39-5)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Heating;

DOI:10.1002/jlcr.2580340708

upstream raw materials:

4-Fluorophenol

4-methoxy-benzoyl chloride

4-fluoroboronic acid

4-methoxy-benzaldehyde

Downstream raw materials:

(5-fluoro-2-hydroxyphenyl)(4-methoxyphenyl)methanone

5-fluoro-2-hydroxy-4'-hydroxybenzophenone

Refernces

• 1、 Ritter, Tobias,Su, Wanqi,Xu, Peng. "Decarboxylative Hydroxylation of Benzoic Acids". supporting information. p. 24012 - 24017. Retrieved 2021/10/06.
• 2、 Qin, Changming,Wu, Huayue,Chen, Jiuxi,Liu, Miaochang,Cheng, Jiang,Su, Weike,Ding, Jinchang. "Palladium-catalyzed aromatic esterification of aldehydes with organoboronic acids and molecular oxygen". supporting information; experimental part. p. 1537 - 1540. Retrieved 2009/04/07.