Phosphine oxide, (1-methyl-2-phenylethyl)diphenyl-

Base Information

• Chemical Name: Phosphine oxide, (1-methyl-2-phenylethyl)diphenyl-
• CAS No.: 7302-07-0
• Molecular Formula: C21H21OP
• Molecular Weight: 320.371
• DSSTox Substance ID: DTXSID00466682
• Nikkaji Number: J1.569.093C
• Mol file: 7302-07-0.mol

Synonyms:7302-07-0;Phosphine oxide, (1-methyl-2-phenylethyl)diphenyl-;DTXSID00466682

Chemical Property of Phosphine oxide, (1-methyl-2-phenylethyl)diphenyl-

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 320.133002287
• Heavy Atom Count: 23
• Complexity: 365

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Phosphine oxide, (1-methyl-2-phenylethyl)diphenyl-

There total 9 articles about Phosphine oxide, (1-methyl-2-phenylethyl)diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-propenylbenzene (873-66-5) + diphenylphosphane (829-85-6) → diphenyl(1-phenylpropan-2-yl)phosphine oxide (7302-07-0)

Guidance literature:

1-propenylbenzene; diphenylphosphane; With [Yb(η²-Ph2CNPh))(hmpa)3]; In tetrahydrofuran; at 20 ℃; for 4h;

With dihydrogen peroxide;

DOI:10.1021/jo030163g

Reference yield: 75.0%

(E)-diphenyl(1-phenylprop-1-en-2-yl)phosphine oxide (62556-17-6) → diphenyl(1-phenylpropan-2-yl)phosphine oxide (7302-07-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 24h; Ambient temperature;

Reference yield: 57.0%

3-phenyl-2-propanol (698-87-3,14898-87-4) + Diphenylphosphine oxide (4559-70-0) → diphenyl(1-phenylpropan-2-yl)phosphine oxide (7302-07-0)

Guidance literature:

With sodium t-butanolate; In N,N-dimethyl acetamide; at 130 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c8ob01299g

upstream raw materials:

triphenyl(prop-1-en-2-yl)phosphonium bromide

phenyllithium

(E)-diphenyl(1-phenylprop-1-en-2-yl)phosphine oxide

1-propenylbenzene

Downstream raw materials:

(S)-2-(Diphenyl-phosphinoyl)-2-methyl-1,6-diphenyl-hexane-3,4-diol

(2R,3R,4S)-2-(Diphenyl-phosphinoyl)-2-methyl-1,6-diphenyl-hexane-3,4-diol

(S)-2-(Diphenyl-phosphinoyl)-2,5,5-trimethyl-1-phenyl-hexane-3,4-diol

(2R,3R,4S)-2-(Diphenyl-phosphinoyl)-2,5,5-trimethyl-1-phenyl-hexane-3,4-diol

Refernces

• 1、 Takaki, Ken,Koshoji, Go,Komeyama, Kimihiro,Takeda, Mitsuhiro,Shishido, Tetsuya,Kitani, Akira,Takehira, Katsuomi. "Intermolecular hydrophosphination of alkynes and related carbon-carbon multiple bonds catalyzed by organoytterbiums". . p. 6554 - 6565. Retrieved 2007/10/03.
• 2、 Takaki, Ken,Takeda, Mitsuhiro,Koshoji, Go,Shishido, Tetsuya,Takehira, Katsuomi. "Intermolecular hydrophosphination of alkynes and related carbon-carbon multiple bonds catalyzed by ytterbium-imine complexes". . p. 6357 - 6360. Retrieved 2007/10/03.