Benzamide, 2-iodo-N-(phenylmethyl)-

Base Information

• Chemical Name: Benzamide, 2-iodo-N-(phenylmethyl)-
• CAS No.: 73178-23-1
• Molecular Formula: C14H12INO
• Molecular Weight: 337.16
• Mol file: 73178-23-1.mol

Synonyms:2-iodo-benzoic acid benzylamide;N-benzyl-2-iodobenzamide;2-Jod-benzoesaeure-benzylamid;2-Jod-N-benzyl-benzamid;2-iodobenzamide;

Chemical Property of Benzamide, 2-iodo-N-(phenylmethyl)-

Chemical Property:

• PSA: 29.10000
• LogP: 3.61210

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyl-2-iodobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 2-iodo-N-(phenylmethyl)-

There total 11 articles about Benzamide, 2-iodo-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Iodobenzoic acid (88-67-5) + benzylamine (100-46-9) → N-benzyl-2-iodobenzamide (73178-23-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 12h;

DOI:10.1002/chem.201200215

Reference yield: 98.0%

1,1,1,3,3,3-hexafluoropropan-2-yl 2-iodobenzoate + benzylamine (100-46-9) → N-benzyl-2-iodobenzamide (73178-23-1)

Guidance literature:

In acetonitrile; at 20 ℃; for 12h;

DOI:10.1055/s-0034-1381056

Reference yield: 72.0%

2-Iodobenzoyl chloride (609-67-6) + benzylamine (100-46-9) → N-benzyl-2-iodobenzamide (73178-23-1)

Guidance literature:

In benzene; for 1h;

upstream raw materials:

ethyl 2-iodobenzoate

benzylamine

o-iodo-methyl-benzoic acid

phenylzinc chloride

Downstream raw materials:

C₁₄H₁₂Cl₂INO

(Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one

1-oxo-3-methyl-2-phenylmethyl-1,2-dihydroisoquinoline

N-benzyl-2-[(4-chlorophenyl)ethynyl]benzamide

Refernces

• 1、 Kim, Soo-Kyoung,Ngo, Huy X.,Dennis, Emily K.,Thamban Chandrika, Nishad,Deshong, Philip,Garneau-Tsodikova, Sylvie,Lee, Vincent T.. "Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues". . p. 1713 - 1726. Retrieved 2021/05/10.
• 2、 Wang, Yingying,Zhou, Yang,Lei, Min,Hou, Jinjun,Jin, Qinghao,Guo, Dean,Wu, Wanying. "PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides". supporting information. p. 1180 - 1185. Retrieved 2019/01/26.