3-ETHYL-2-HYDROXYBENZALDEHYDE

Base Information

• Chemical Name: 3-ETHYL-2-HYDROXYBENZALDEHYDE
• CAS No.: 73289-91-5
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Mol file: 73289-91-5.mol

Synonyms:3-Aethyl-2-hydroxy-benzaldehyd;5-Aethyl-salicylaldehyd;3-ethyl-salicylaldehyde;3-Aethyl-salicylaldehyd;3-ethyl-2-hydroxy-benzaldehyde;

Chemical Property of 3-ETHYL-2-HYDROXYBENZALDEHYDE

Chemical Property:

• PSA: 37.30000
• LogP: 1.76710

Purity/Quality:

95+% ^*data from raw suppliers

3-Ethylsalicylaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Ethylsalicylaldehyde is an intermediate in the synthesis of thiosemicarbazones, inhibitors of lysophosphatidic acid acyltransferase.

Technology Process of 3-ETHYL-2-HYDROXYBENZALDEHYDE

There total 8 articles about 3-ETHYL-2-HYDROXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

o-Hydroxyethylbenzene (90-00-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 2-hydroxy-3-ethylbenzaldehyde (73289-91-5)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile; at 20 ℃; for 17h; Reflux;

DOI:10.1016/j.tetasy.2014.08.002

Reference yield: 78.0%

o-Hydroxyethylbenzene (90-00-6) → 2-hydroxy-3-ethylbenzaldehyde (73289-91-5)

Guidance literature:

With triethylamine; magnesium chloride; for 7h; Reflux;

Reference yield: 55.0%

o-Hydroxyethylbenzene (90-00-6) + p-formaldehyde → 2-hydroxy-3-ethylbenzaldehyde (73289-91-5)

Guidance literature:

With tributyl-amine; tin(IV) chloride; In toluene; at 20 - 100 ℃;

upstream raw materials:

o-Hydroxyethylbenzene

hydrogen cyanide

hexamethylenetetramine

metaboric acid

Downstream raw materials:

(S)-2-tosyloxy-1-(7-ethylbenzofuran-2-yl)ethanol

3-ethyl-2-hydroxy-5-nitrobenzaldehyde

2-(2-benzyloxy-3-ethylphenyl)-1-(methylthio)vinyl methyl sulfoxide

methyl (2-benzyloxy-3-ethylphenyl)acetate

Refernces

• 1、 Ikeuchi, Takaya,Inuki, Shinsuke,Oishi, Shinya,Ohno, Hiroaki. "Gold(I)-Catalyzed Cascade Cyclization Reactions of Allenynes for the Synthesis of Fused Cyclopropanes and Acenaphthenes". supporting information. p. 7792 - 7796. Retrieved 2019/05/15.
• 2、 -. "THIOSEMICARBAZONES INHIBITORS OF LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE AND USES THEREOF". Page/Page column 15. . Retrieved 2015/11/17.