Benzeneacetic acid, a-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-oxo-, 1,1-dimethylethyl ester
• CAS No.: 7332-98-1
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol file: 7332-98-1.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-oxo-, 1,1-dimethylethyl ester

There total 34 articles about Benzeneacetic acid, a-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(Methyl-p-tolyl-hydrazono)-phenyl-acetic acid tert-butyl ester (177540-35-1) → N-methyl-N-nitroso-p-toluidine (937-24-6) + tert-butyl phenylglyoxylate (7332-98-1)

Guidance literature:

With ozone; In dichloromethane;

DOI:10.1016/0040-4020(96)00219-0

Reference yield: 96.0%

tert-butyl 2-diazo-2-phenylacetate (72410-67-4) → tert-butyl phenylglyoxylate (7332-98-1)

Guidance literature:

With water; diethylazodicarboxylate; dirhodium tetraacetate; In toluene; for 4h; Heating;

DOI:10.1055/s-2006-950412

Reference yield: 92.0%

Benzoylformic acid (611-73-4) + tert-butyl alcohol (75-65-0) → tert-butyl phenylglyoxylate (7332-98-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In benzene; 1.) ice bath, 10 min, 2.) room tenperature, 8 h.;

DOI:10.1021/jo960685e

upstream raw materials:

Benzoylformic acid

isobutene

bromobenzene

tert-butyl α-oxo-1H-imidazole-1-acetate

Downstream raw materials:

1-tert-Butyl-4-ethyl-2-hydroxy-2-phenylsuccinat

tert-Butyl-3,3-diethoxy-2-phenyl-2-oxetancarboxylat

Hexamethyldisiloxane

Phenyl-[(Z)-trimethylsilanyl-imino]-acetic acid tert-butyl ester

Refernces

• 1、 Ang, Esther Cai Xia,Tan, Choon-Hong,Ye, Xinyi. "Preparation of asymmetric phase-transfer catalyst, 1,4-bis((4s,5s)-1,3-bis(3,5-di-tert-butylbenzyl)-4,5-diphenylimidazolidin-2-ylidene)piperazine-1,4-diium chloride". . p. 274 - 293. Retrieved 2020/10/12.
• 2、 Zhou, Juan,Mock, Elliot D.,Al Ayed, Karol,Di, Xinyu,Kantae, Vasudev,Burggraaff, Lindsey,Stevens, Anna F.,Martella, Andrea,Mohr, Florian,Jiang, Ming,Van Der Wel, Tom,Wendel, Tiemen J.,Ofman, Tim P.,Tran, Yvonne,De Koster, Nicky,Van Westen, Gerard J.P.,Hankemeier, Thomas,Van Der Stelt, Mario. "Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family". . p. 9340 - 9359. Retrieved 2020/10/19.